SG ID

SG00001917 

UniProt Accession

G3V7F5_RAT;G3V7F5;  

Theoretical PI

5.89  

Molecular Weight

65285 Da  

Genbank Nucleotide ID

CH473957;  

Genbank Protein ID

EDL91388.1; 

Gene Name

Nr2c2 

Gene Synonyms/Alias

ORFNames=rCG_56527 

Protein Name

 

Protein Synonyms/Alias

SubName: Nuclear receptor subfamily 2 group C member 2SubName: RCG56527, isoform CRA_c 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. X. Mu, L. Yang and C. Chang (2006) Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis. Biochem Biophys Res Commun 341(2): 464-9. 

Abstract
In this study, we investigated the expression of TR4 in different stages of seminiferous tubules and the relationship between TR4 and androgen in rat testis. We found that TR4 was stage-dependently expressed in rat seminiferous tubules, T withdrawal induced by high doses of testosterone undecanoate and ethane dimethane sulfonate inhibit TR4 expression in rat testis, and testosterone induced TR4 expression in co-cultured primary germ/Sertoli cells. Furthermore, we demonstrated that androgen receptor could enhance TR4-mediated transactivation activity in testis cells in the presence of testosterone. Together, these data indicate that the expression of TR4 in rat testis is stage dependent and androgen inductive, and suggest the important role of orphan receptor TR4 in spermatogenesis. PMID: [16414012] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005634	C:nucleus	IEA:UniProtKB-KW.
GO:0043565	F:sequence-specific DNA binding	IEA:InterPro.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IEA:InterPro.
GO:0003707	F:steroid hormone receptor activity	IEA:InterPro.
GO:0008270	F:zinc ion binding	IEA:InterPro.
GO:0006351	P:transcription, DNA-dependent	IEA:UniProtKB-KW.

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Interpro

IPR008946;    Nucl_hormone_rcpt_ligand-bd.
IPR000536;    Nucl_hrmn_rcpt_lig-bd_core.
IPR001723;    Str_hrmn_rcpt.
IPR001628;    Znf_hrmn_rcpt.
IPR013088;    Znf_NHR/GATA.
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Pfam

PF00104;    Hormone_recep;    1.
PF00105;    zf-C4;    1.
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SMART

SM00430;    HOLI;    1.
SM00399;    ZnF_C4;    1.
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PROSITE

PS00031;    NUCLEAR_REC_DBD_1;    1.
PS51030;    NUCLEAR_REC_DBD_2;    1.
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PRINTS

PR00398;    STRDHORMONER.;   
PR00047;    STROIDFINGER.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 596 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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