SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001960 
UniProt Accession
Theoretical PI
5.49  
Molecular Weight
64241 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Tgfbr2 
Gene Synonyms/Alias
 
Protein Name
TGF-beta receptor type-2 
Protein Synonyms/Alias
TGFR-2EC=2.7.11.30 TGF-beta type II receptor; Transforming growth factor-beta receptor type II;TGF-beta receptor type IITbetaR-IIFlags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:8;120593595-120680453;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. J. L. Yuan, Y. T. Zhang and Y. Wang (2010) Increased apoptosis of spermatogenic cells in cryptorchidism rat model and its correlation with transforming growth factor beta type II receptor. Urology 75(4): 992-8. 

Abstract
OBJECTIVES PMID: [19931125] 

2. R. Olaso, C. Pairault and R. Habert (1998) Expression of type I and II receptors for transforming growth factor beta in the adult rat testis. Histochem Cell Biol 110(6): 613-8. 

Abstract
After having established the specificity of the antibodies for the rat testis by western blot analysis, the potential target cells for transforming growth factors (TGFbetas) were identified by immunohistochemical detection of both type I (TbetaRI) and type II (TbetaRII) transducing receptors for TGFbetas in the adult rat testis in situ. Leydig cells showed a strong TbetaRII immunoreactivity whereas the TbetaRI staining was weak. Only TbetaRII was detectable in Sertoli cells. In germ cells, staining for TbetaRI was stronger than for TbetaRII and the expression of both receptors depended on the seminiferous cycle stage. TbetaRI first appeared in pachytene spermatocytes and was absent in elongated spermatids from stage XIV onwards. Labelling for TbetaRII was observed as early as the spermatogonia stage; it increased in pachytene spermatocytes at the onset of TbetaRI and disappeared in elongating spermatids from stage XI onwards. These results show that TGFbetas can affect somatic cells functions and suggest that these factors are involved in the control of meiosis and early spermiogenesis, exerting a direct effect on germ cells. PMID: [9860260] 

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Figures for illustrating the function of this protein/gene
Function
Transmembrane serine/threonine kinase forming with theTGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 andTGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cellsurface to the cytoplasm and is thus regulating a plethora ofphysiological and pathological processes including cell cyclearrest in epithelial and hematopoietic cells, control ofmesenchymal cell proliferation and differentiation, wound healing,extracellular matrix production, immunosuppression andcarcinogenesis. The formation of the receptor complex composed of2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to thecytokine dimer results in the phosphorylation and the activationof TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1phosphorylates SMAD2 which dissociates from the receptor andinteracts with SMAD4. The SMAD2-SMAD4 complex is subsequentlytranslocated to the nucleus where it modulates the transcriptionof the TGF-beta-regulated genes. This constitutes the canonicalSMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (Bysimilarity). 
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Subcellular Location
Cell membrane; Single-pass type I membraneprotein. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005901 C:caveola IDA:MGI.
GO:0009986 C:cell surface IDA:RGD.
GO:0005829 C:cytosol IDA:RGD.
GO:0005624 C:membrane fraction IDA:RGD.
GO:0070022 C:transforming growth factor beta receptor homodimeric complex IC:RGD.
GO:0005524 F:ATP binding IEA:UniProtKB-KW.
GO:0046872 F:metal ion binding IEA:UniProtKB-KW.
GO:0004702 F:receptor signaling protein serine/threonine kinase activity IEA:InterPro.
GO:0005026 F:transforming growth factor beta receptor activity, type II IMP:RGD.
GO:0007568 P:aging IEP:RGD.
GO:0006915 P:apoptotic process IEA:UniProtKB-KW.
GO:0007182 P:common-partner SMAD protein phosphorylation IDA:RGD.
GO:0048565 P:digestive tract development IEP:RGD.
GO:0009790 P:embryo development IEP:RGD.
GO:0007566 P:embryo implantation IEP:RGD.
GO:0030324 P:lung development IEP:RGD.
GO:0060044 P:negative regulation of cardiac muscle cell proliferation IMP:RGD.
GO:0031100 P:organ regeneration IEP:RGD.
GO:0043415 P:positive regulation of skeletal muscle tissue regeneration IEP:RGD.
GO:0048661 P:positive regulation of smooth muscle cell proliferation IMP:RGD.
GO:0006898 P:receptor-mediated endocytosis IDA:RGD.
GO:0043627 P:response to estrogen stimulus IEP:RGD.
GO:0009749 P:response to glucose stimulus IEP:RGD.
GO:0001666 P:response to hypoxia IEP:RGD.
GO:0009612 P:response to mechanical stimulus IEP:RGD.
GO:0007584 P:response to nutrient IEP:RGD.
GO:0014070 P:response to organic cyclic compound IEP:RGD.
GO:0023014 P:signal transduction by phosphorylation IEA:GOC.
GO:0007179 P:transforming growth factor beta receptor signaling pathway IMP:RGD.
GO:0001570 P:vasculogenesis IEP:RGD.
GO:0042060 P:wound healing IEP:RGD.
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Interpro
IPR000333;    Activin_II/TGFBeta-II_recpt.
IPR011009;    Kinase-like_dom.
IPR000719;    Prot_kinase_cat_dom.
IPR017441;    Protein_kinase_ATP_BS.
IPR008271;    Ser/Thr_kinase_AS.
IPR017194;    Transform_growth_fac-b_typ-2.
IPR015013;    Transforming_GF_b_rcpt_2_ecto.
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Pfam
PF08917;    ecTbetaR2;    1.
PF00069;    Pkinase;    1.
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SMART
PROSITE
PS00107;    PROTEIN_KINASE_ATP;    1.
PS50011;    PROTEIN_KINASE_DOM;    1.
PS00108;    PROTEIN_KINASE_ST;    1.
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PRINTS
PR00653;    ACTIVIN2R.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     23       Potential.
CHAIN        24    567       TGF-beta receptor type-2.
                             /FTId=PRO_0000024429.
TOPO_DOM     24    166       Extracellular (Potential).
TRANSMEM    167    187       Helical; (Potential).
TOPO_DOM    188    567       Cytoplasmic (Potential).
DOMAIN      244    546       Protein kinase.
NP_BIND     250    258       ATP (By similarity).
ACT_SITE    379    379       Proton acceptor (By similarity).
BINDING     277    277       ATP (By similarity).
MOD_RES     409    409       Phosphoserine (By similarity).
MOD_RES     548    548       Phosphoserine (By similarity).
MOD_RES     551    551       Phosphoserine (By similarity).
MOD_RES     553    553       Phosphoserine (By similarity).
CARBOHYD     70     70       N-linked (GlcNAc...) (Potential).
CARBOHYD     94     94       N-linked (GlcNAc...) (Potential).
DISULFID     51     84       By similarity.
DISULFID     54     71       By similarity.
DISULFID     61     67       By similarity.
DISULFID     77    101       By similarity.
DISULFID    121    136       By similarity.
DISULFID    138    143       By similarity.
CONFLICT    388    389       KN -> RS (in Ref. 2; AAB29352).
CONFLICT    403    403       R -> G (in Ref. 2; AAB29352).
CONFLICT    405    405       D -> S (in Ref. 2; AAB29352).
CONFLICT    477    477       K -> R (in Ref. 2; AAB29352).
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Nucleotide Sequence
Length: 1792 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 567 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Tgfbr1IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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