SG ID

SG00001972 

UniProt Accession

F8WFS1_RAT;F8WFS1;  

Theoretical PI

5.57  

Molecular Weight

155524 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Igf1r 

Gene Synonyms/Alias

 

Protein Name

Tyrosine-protein kinase receptor 

Protein Synonyms/Alias

EC=2.7.10.1 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. A. Yagci and B. Zik (2006) Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes. Anat Histol Embryol 35(5): 305-9. 

Abstract
It has been suggested that insulin-like growth factor-I (IGF-I) plays an important role in the regulation of spermatogenesis in the testes. Its signal is mediated predominantly by the IGF-I receptor (IGF-IR). Signalling through IGF-IR has been shown to have a potent survival function. IGF-IR, a transmembrane tyrosine kinase, is widely expressed across many cell types. In this study, we demonstrated the distribution of IGF-IR in testes of differently aged rats. Anti-IGF-IR is a rabbit polyclonal antibody raised against a peptide mapping at the carboxy terminus of the IGF-IR of human origin. Testicular specimens were fixed in Bouin's solution and embedded in paraffin. The paraffin-embedded sections were processed for standard immunohistochemistry by the labelled streptavidin-biotin technique. At postnatal day 19, IGF-IR immunoreactivity was seen moderately in spermatogonia, and slightly both in leptotene and zygotene primary spermatocytes. At postnatal day 35, immunoreactivity was seen slightly both in the pachytene primary spermatocytes and Leydig cells. Although there was intense immunoreactivity in the Leydig cells and in the elongated spermatids on days 50 and 70, the intensity of reaction was decreased in the elongated spermatids in the 10th month. Our results suggest that IGF-IR may play significant roles in testicular function and germ cell development. PMID: [16968249] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0005524	F:ATP binding	IEA:UniProtKB-KW.
GO:0004714	F:transmembrane receptor protein tyrosine kinase activity	IEA:EC.
GO:0046777	P:protein autophosphorylation	IEA:InterPro.
GO:0007169	P:transmembrane receptor protein tyrosine kinase signaling pathway	IEA:InterPro.

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Interpro

IPR000494;    EGF_rcpt_L.
IPR003961;    Fibronectin_type3.
IPR006211;    Furin-like_Cys-rich_dom.
IPR006212;    Furin_repeat.
IPR009030;    Growth_fac_rcpt.
IPR013783;    Ig-like_fold.
IPR011009;    Kinase-like_dom.
IPR000719;    Prot_kinase_cat_dom.
IPR017441;    Protein_kinase_ATP_BS.
IPR001245;    Ser-Thr/Tyr_kinase_cat_dom.
IPR008266;    Tyr_kinase_AS.
IPR020635;    Tyr_kinase_cat_dom.
IPR016246;    Tyr_kinase_insulin-like_rcpt.
IPR002011;    Tyr_kinase_rcpt_2_CS.
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Pfam

PF00041;    fn3;    1.
PF00757;    Furin-like;    1.
PF07714;    Pkinase_Tyr;    1.
PF01030;    Recep_L_domain;    2.
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SMART

SM00060;    FN3;    3.
SM00261;    FU;    1.
SM00219;    TyrKc;    1.
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PROSITE

PS50853;    FN3;    3.
PS00107;    PROTEIN_KINASE_ATP;    1.
PS50011;    PROTEIN_KINASE_DOM;    1.
PS00109;    PROTEIN_KINASE_TYR;    1.
PS00239;    RECEPTOR_TYR_KIN_II;    1.
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PRINTS

PR00109;    TYRKINASE.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1371 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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