SG ID

SG00001979 

UniProt Accession

MAS_RAT;P12526;  

Theoretical PI

8.72  

Molecular Weight

37131 Da  

Genbank Nucleotide ID

J03823; BC078884;  

Genbank Protein ID

AAA41573.1; AAH78884.1; 

Gene Name

Mas1 

Gene Synonyms/Alias

Mas, Mas-1 

Protein Name

Proto-oncogene Mas 

Protein Synonyms/Alias

 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. M. C. Leal, S. V. Pinheiro, A. J. Ferreira, R. A. Santos, L. S. Bordoni, N. Alenina, M. Bader and L. R. Franca (2009) The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats. J Anat 214(5): 736-43. 

Abstract
Evidence regarding the components of the renin-angiotensin (Ang) system suggests that this system plays an important role in male reproduction. However, there are few data available in the literature on the effects of Ang-(1-7) on the male reproductive system. The present study investigated the effects of the genetic deletion and chronic blockage of Ang-(1-7) receptor Mas on spermatogenesis and male fertility. The localization of Mas in mouse and rat testes was determined by binding assays and immunofluorescence, whereas the testis structure and spermatogenic process were morphologically and stereologically analysed by light microscopy. Ang-(1-7) binding and immunofluorescence revealed the presence of Mas in the testes of mice and rats. Although the total numbers of Sertoli and Leydig cells per testis and Leydig cell size were similar in both wild-type and Mas-deficient mice, Mas(-/-) animals exhibited a significant reduction in testis weight and a greater volume of apoptotic cells, giant cells and vacuoles in the seminiferous epithelium. In both mice and rats, an increased number of apoptotic cells were found during meiosis. Due to disturbed spermatogenesis, daily sperm production was markedly reduced in Mas(-/-) mice. Moreover, chronic infusion of A-779 [an Ang-(1-7) antagonist] in rats significantly increased the total number of apoptotic cells and primary spermatocytes in particular stages of spermatogenesis. Taken together, these findings strongly suggest that Ang-(1-7) receptor Mas plays an important role in the regulation of spermatogenesis. PMID: [19438767] 

Figures for illustrating the function of this protein/gene

Function

Receptor for angiotensin 1-7 (By similarity). Actsspecifically as a functional antagonist of AGTR1 (angiotensin-2type 1 receptor), although it up-regulates AGTR1 receptor levels.Positive regulation of AGTR1 levels occurs through activation ofthe G-proteins GNA11 and GNAQ, and stimulation of the proteinkinase C signaling cascade. The antagonist effect on AGTR1function is probably due to AGTR1 being physically altered by MAS1(By similarity). 

Subcellular Location

Cell membrane; Multi-pass membrane protein. 

Tissue Specificity

Expressed in platelets. 

Gene Ontology

GO ID	GO term	Evidence
GO:0009986	C:cell surface	IDA:RGD.
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0005886	C:plasma membrane	IEA:UniProtKB-SubCell.
GO:0001595	F:angiotensin receptor activity	IMP:RGD.
GO:0017046	F:peptide hormone binding	IMP:RGD.
GO:0007250	P:activation of NF-kappaB-inducing kinase activity	IEA:Compara.
GO:0071375	P:cellular response to peptide hormone stimulus	IEP:RGD.
GO:0021766	P:hippocampus development	IEP:RGD.
GO:0008584	P:male gonad development	IEP:RGD.
GO:0001933	P:negative regulation of protein phosphorylation	IMP:RGD.
GO:0008284	P:positive regulation of cell proliferation	IDA:RGD.
GO:0045740	P:positive regulation of DNA replication	IDA:RGD.
GO:0060732	P:positive regulation of inositol phosphate biosynthetic process	IDA:RGD.
GO:0070528	P:protein kinase C signaling cascade	IEA:Compara.
GO:0050727	P:regulation of inflammatory response	IEA:Compara.
GO:0014823	P:response to activity	IEP:RGD.
GO:0042493	P:response to drug	IEP:RGD.
GO:0034698	P:response to gonadotropin stimulus	IEP:RGD.
GO:0007283	P:spermatogenesis	IMP:RGD.

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Interpro

IPR000276;    7TM_GPCR_Rhodpsn.
IPR017452;    GPCR_Rhodpsn_supfam.
IPR000820;    Proto-oncogene_Mas.
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Pfam

PF00001;    7tm_1;    1.
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SMART

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PROSITE

PS00237;    G_PROTEIN_RECEP_F1_1;    1.
PS50262;    G_PROTEIN_RECEP_F1_2;    1.
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PRINTS

PR00237;    GPCRRHODOPSN.;   
PR00533;    MASONCOGENE.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1155 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 324 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt	Gene Symbol	Ref Databases
ACE_RAT	Ace	String
ANGT_RAT	Agt	String
CAH4_RAT	Car4	String
CBG_RAT	Serpina6	String
CP17A_RAT	Cyp17a1	String
CP19A_RAT	LOC100359906	String
EGR3_RAT	Egr3	String
FYN_RAT	Fyn	String
JUN_RAT	Jun	String
KSYK_RAT	Syk	String
ACE_RAT	Ace	String
ANGT_RAT	Agt	String
CAH4_RAT	Car4	String
CBG_RAT	Serpina6	String
CP17A_RAT	Cyp17a1	String
CP19A_RAT	LOC100359906	String
EGR3_RAT	Egr3	String
FYN_RAT	Fyn	String
JUN_RAT	Jun	String
KSYK_RAT	Syk	String
NMS_RAT	NMS	String
PTN6_RAT	Ptpn6	String
RENI_RAT	Ren	String
NMS_RAT	NMS	String
PTN6_RAT	Ptpn6	String
RENI_RAT	Ren	String

View Microarray data

Temporarily unavailable 

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