SG ID

SG00001986 

UniProt Accession

F1M8H8_RAT;F1M8H8;  

Theoretical PI

5.84  

Molecular Weight

62107 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Habp2 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Hyaluronan-binding protein 2 50 kDa heavy chain 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. S. C. Thakur, V. Kumar, I. Ghosh, A. Bharadwaj and K. Datta (2006) Appearance of hyaluronan binding protein 1 proprotein in pachytene spermatocytes and round spermatids correlates with spermatogenesis. J Androl 27(4): 604-10. 

Abstract
The proprotein form of hyaluronan binding protein 1 (HABP1) has been reported to be present in the pachytene spermatocytes and the round spermatids of the adult testis. To explore the role of HABP1 proprotein in spermatogenesis, its expression in the testes of adult rats was compared with that in the testes of developing rats and that in the testes of adult rats that received estriadiol to halt spermatogenesis. Immunoblotting revealed that the mature form of HABP1 was consistently present in the testis, but its precursor form was not found in the testis of animals aged 7, 14, 21, and 28 days. However, immunohistochemical analysis revealed the presence of the proprotein form in the pachytene spermatocytes and the round spermatids of testes from rats aged 21 and the 28 days, the appearance of which correlated well with the appearance of these cells during spermatogenesis. Reverse-transcriptase polymerase chain reaction revealed transcriptional upregulation of HABP1 in the testes of adult rats, compared with the testes of developing rats. Finally, loss of HABP1 proprotein expression from the pachytene spermatocytes and round spermatids was observed in the testes from rats in which spermatogenesis was arrested. Collectively, these findings demonstrate the appearance of HABP1 proprotein in the pachytene spermatocytes and the round spermatids during the initial stages of postnatal testis development and suggest that this expression may be crucial for spermatogenesis. PMID: [16582418] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0004252	F:serine-type endopeptidase activity	IEA:InterPro.
GO:0006508	P:proteolysis	IEA:UniProtKB-KW.

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Interpro

IPR000742;    EG-like_dom.
IPR006210;    EGF-like.
IPR013032;    EGF-like_CS.
IPR006209;    EGF-like_dom.
IPR000001;    Kringle.
IPR013806;    Kringle-like.
IPR018056;    Kringle_CS.
IPR009003;    Pept_cys/ser_Trypsin-like.
IPR018114;    Peptidase_S1/S6_AS.
IPR001254;    Peptidase_S1_S6.
IPR001314;    Peptidase_S1A.
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Pfam

PF00008;    EGF;    2.
PF00051;    Kringle;    1.
PF00089;    Trypsin;    1.
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SMART

SM00181;    EGF;    3.
SM00130;    KR;    1.
SM00020;    Tryp_SPc;    1.
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PROSITE

PS00022;    EGF_1;    3.
PS01186;    EGF_2;    2.
PS50026;    EGF_3;    3.
PS00021;    KRINGLE_1;    1.
PS50070;    KRINGLE_2;    1.
PS50240;    TRYPSIN_DOM;    1.
PS00134;    TRYPSIN_HIS;    1.
PS00135;    TRYPSIN_SER;    1.
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PRINTS

PR00722;    CHYMOTRYPSIN.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 558 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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