SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001989 
UniProt Accession
Theoretical PI
6.76  
Molecular Weight
77681 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Fshr 
Gene Synonyms/Alias
 
Protein Name
Follicle-stimulating hormone receptor 
Protein Synonyms/Alias
FSH-R Follitropin receptor;Flags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:6;12865503-13161215;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. D. Segretain, J. Gilleron, D. Carette, J. P. Denizot and G. Pointis (2010) Differential time course of FSH/FSH receptor complex endocytosis within sertoli and germ cells during rat testis development. Dev Dyn 239(4): 1113-23. 

Abstract
Follicle-stimulating hormone (FSH) is required for initiation and maintenance of spermatogenesis, a dynamic process of cell proliferation and maturation. By using FSH-gold particles and pulse-chase experiments, we analyzed the kinetics of FSH endocytosis in Sertoli and germ cells during development. Ultrastructural time-dependent analysis demonstrates that FSH was first located on plasma membrane, before being accumulated within the endosomal compartment, in the early endosomes, identified by morphological criteria and Rab-5 colocalization. Thereafter, FSH-gold was routed to the degradation pathway. The FSH endocytosis kinetic was similar in Sertoli cells, spermatogonia and spermatocytes. However, quantitative analysis of gold particles revealed differences in the dynamic of FSH accumulation in the endosomes between immature and mature rats. This age-dependent kinetic of FSH endocytosis, mostly detectable by ultrastructural analysis associated with quantitative data, argues for a potential new regulatory mechanism of the FSH signalling pathway that could occur during maturation of testicular cells. PMID: [20201104] 

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Figures for illustrating the function of this protein/gene
Function
Receptor for follicle-stimulating hormone. The activityof this receptor is mediated by G proteins which activateadenylate cyclase. 
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Subcellular Location
Cell membrane; Multi-pass membrane protein. 
Tissue Specificity
Sertoli cells and ovarian granulosa cells. 
Gene Ontology
GO IDGO termEvidence
GO:0009986 C:cell surface IDA:RGD.
GO:0005768 C:endosome IDA:RGD.
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell.
GO:0004963 F:follicle-stimulating hormone receptor activity IDA:RGD.
GO:0017046 F:peptide hormone binding IDA:RGD.
GO:0007189 P:adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA:RGD.
GO:0008584 P:male gonad development IEA:Compara.
GO:0033044 P:regulation of chromosome organization IEA:Compara.
GO:0035093 P:spermatogenesis, exchange of chromosomal proteins IEA:Compara.
GO:0045056 P:transcytosis IDA:RGD.
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Interpro
IPR000276;    7TM_GPCR_Rhodpsn.
IPR002272;    FSH_rcpt.
IPR024635;    GnHR_TM.
IPR017452;    GPCR_Rhodpsn_supfam.
IPR002131;    Gphrmn_rcpt.
IPR001611;    Leu-rich_rpt.
IPR000372;    LRR-contain_N.
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Pfam
PF00001;    7tm_1;    1.
PF12369;    GnHR_trans;    1.
PF01462;    LRRNT;    1.
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SMART
SM00013;    LRRNT;    1.
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PROSITE
PS00237;    G_PROTEIN_RECEP_F1_1;    1.
PS50262;    G_PROTEIN_RECEP_F1_2;    1.
PS51450;    LRR;    3.
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PRINTS
PR01143;    FSHRECEPTOR.;   
PR00373;    GLYCHORMONER.;   
PR00237;    GPCRRHODOPSN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     17       Potential.
CHAIN        18    692       Follicle-stimulating hormone receptor.
                             /FTId=PRO_0000012775.
TOPO_DOM     18    365       Extracellular (Potential).
TRANSMEM    366    386       Helical; Name=1; (Potential).
TOPO_DOM    387    397       Cytoplasmic (Potential).
TRANSMEM    398    420       Helical; Name=2; (Potential).
TOPO_DOM    421    442       Extracellular (Potential).
TRANSMEM    443    464       Helical; Name=3; (Potential).
TOPO_DOM    465    484       Cytoplasmic (Potential).
TRANSMEM    485    507       Helical; Name=4; (Potential).
TOPO_DOM    508    527       Extracellular (Potential).
TRANSMEM    528    549       Helical; Name=5; (Potential).
TOPO_DOM    550    572       Cytoplasmic (Potential).
TRANSMEM    573    596       Helical; Name=6; (Potential).
TOPO_DOM    597    607       Extracellular (Potential).
TRANSMEM    608    629       Helical; Name=7; (Potential).
TOPO_DOM    630    692       Cytoplasmic (Potential).
DOMAIN       18     46       LRRNT.
REPEAT       49     72       LRR 1.
REPEAT       73     97       LRR 2.
REPEAT       98    118       LRR 3.
REPEAT      119    143       LRR 4.
REPEAT      144    169       LRR 5.
REPEAT      170    192       LRR 6.
REPEAT      193    216       LRR 7.
REPEAT      217    240       LRR 8.
REPEAT      241    259       LRR 9.
CARBOHYD    191    191       N-linked (GlcNAc...).
CARBOHYD    199    199       N-linked (GlcNAc...) (Potential).
CARBOHYD    293    293       N-linked (GlcNAc...).
DISULFID     18     25       By similarity.
DISULFID     23     32       By similarity.
DISULFID    441    516       By similarity.
MUTAGEN     191    191       N->Q: Reduces N-glycosylation level.
MUTAGEN     199    199       N->Q: Does not affect N-glycosylation
                             level.
MUTAGEN     293    293       N->Q: Reduces N-glycosylation level.
MUTAGEN     387    387       T->I: Reduces interaction with ARRB2;
                             when associated with I-389 and N-394.
MUTAGEN     389    389       S->I: Reduces interaction with ARRB2;
                             when associated with I-387 and N-394.
MUTAGEN     394    394       T->N: Reduces interaction with ARRB2;
                             when associated with I-387 and I-389.
MUTAGEN     407    407       D->N: Reduces interaction with ARRB2.
MUTAGEN     548    548       Y->F: Reduces interaction with ARRB2.
CONFLICT    172    175       Missing (in Ref. 2; AAB21415).
CONFLICT    252    252       L -> W (in Ref. 2; AAB21415).
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Nucleotide Sequence
Length: 2366 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 692 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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