SG ID

SG00001991 

UniProt Accession

GFRA1_RAT;Q62997;  

Theoretical PI

8.41  

Molecular Weight

51650 Da  

Genbank Nucleotide ID

U59486; U97142;  

Genbank Protein ID

AAC52663.1; AAC53300.1; 

Gene Name

Gfra1 

Gene Synonyms/Alias

Gdnfra, Retl1, Trnr1 

Protein Name

GDNF family receptor alpha-1 

Protein Synonyms/Alias

GDNF receptor alpha-1GDNFR-alpha-1GFR-alpha-1 RET ligand 1; TGF-beta-related neurotrophic factor receptor 1;Flags: Precursor 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. S. Fouchecourt, M. Godet, O. Sabido and P. Durand (2006) Glial cell-line-derived neurotropic factor and its receptors are expressed by germinal and somatic cells of the rat testis. J Endocrinol 190(1): 59-71. 

Abstract
Glial cell-line-derived neurotropic factor (GDNF) and its receptors glial cell-line-derived neurotropic factor alpha (GFR1alpha) and rearranged during transformation (RET) have been localized in the rat testis during postnatal development. The three mRNAs, and GDNF and GFR1alpha proteins were detected in testis extracts from 1- to 90-day-old rats by reverse transcriptase PCR and Western blotting respectively. The three mRNAs were present in Sertoli cells from 20- and 55-day-old rats, pachytene spermatocytes (PS), and round spermatids (RS). The GDNF and GFR1alpha proteins were detected in PS, RS, and Sertoli cells. GDNF and GFR1alpha were also detected using flow cytometry in spermatogonia and preleptotene spermatocytes, and in secondary spermatocytes. The localization of GDNF and GFR1alpha in germ and Sertoli cells was confirmed by immunocytochemistry. The hypothesis that GDNF may control DNA synthesis of Sertoli cells and/or spermatogonia in the immature rat was addressed using cultures of seminiferous tubules from 7- to 8-day-old rats. Addition of GDNF for 48 h resulted in a twofold decrease in the percentage of spermatogonia able to duplicate DNA, whereas Sertoli cells were not affected. These results are consistent with a role of GDNF in inhibiting the S-phase entrance of a large subset of differentiated type A spermatogonia, together with an enhancing effect of the factor on a small population of undifferentiated (stem cells) spermatogonia. Moreover, the wide temporal and spatial expression of GDNF and its receptors in the rat testis suggest that it might act at several stages of spermatogenesis. PMID: [16837611] 

2. G. Akkoyunlu, T. Erdogru, Y. Seval, I. Ustunel, T. Koksal, M. F. Usta, M. Baykara and R. Demir (2007) Immunolocalization of glial cell-derived neurotrophic factor (GDNF) and its receptor GFR-alpha1 in varicocele-induced rat testis. Acta Histochem 109(2): 130-7. 

Abstract
The aim of the study was to determine the immunolocalisation of glial cell-derived neurotrophic factor (GDNF) and its receptor (GFRalpha1) in testicular dysfunction induced by experimental left varicocele. Male Wistar rats were divided randomly into two groups PMID: [17240430] 

Figures for illustrating the function of this protein/gene

Function

Receptor for GDNF. Mediates the GDNF-inducedautophosphorylation and activation of the RET receptor. 

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. 

Tissue Specificity

Expressed in liver, brain, kidney and cochlea. 

Gene Ontology

GO ID	GO term	Evidence
GO:0031225	C:anchored to membrane	IEA:UniProtKB-KW.
GO:0030424	C:axon	IDA:RGD.
GO:0009897	C:external side of plasma membrane	IDA:RGD.
GO:0005615	C:extracellular space	IDA:RGD.
GO:0043025	C:neuronal cell body	IDA:RGD.
GO:0043235	C:receptor complex	IDA:RGD.
GO:0004872	F:receptor activity	IDA:RGD.
GO:0016477	P:cell migration	IMP:RGD.
GO:0001822	P:kidney development	IEP:RGD.
GO:0008584	P:male gonad development	IEP:RGD.
GO:0031175	P:neuron projection development	IDA:RGD.

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Interpro

IPR016017;    GDNF/GAS1.
IPR003438;    GDNF_rcpt.
IPR003503;    GDNF_rcpt_A1.
IPR017372;    Glial_neurotroph_fac_rcpt_a1/2.
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Pfam

PF02351;    GDNF;    3.
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SMART

SM00907;    GDNF;    3.
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PROSITE

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PRINTS

PR01317;    GDNFRALPHA1.;   
PR01316;    GDNFRECEPTOR.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 2138 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 468 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
A7UGJ1_RAT	Gdnf	BioGRID
GDNF_RAT	Gdnf	BioGRID
NRTN_MOUSE	Nrtn	BioGRID

Other Protein-Protein interaction resources

String database  

UniProt	Gene Symbol	Ref Databases
AKT1_RAT	Akt1	String
ANDR_RAT	Ar	String
ARTN_RAT	Artn	String
BCL2_RAT	Bcl2	String
BMP4_RAT	Bmp4	String
CALB1_RAT	Calb1	String
CALB2_RAT	Calb2	String
CALC_RAT	Calca	String
CDK5_RAT	Cdk5	String
CNTF_RAT	Cntf	String
DHSB_RAT	Sdhb	String
DOPO_RAT	Dbh	String
ECE1_RAT	Ece1	String
EDN1_RAT	Edn1	String
EDN2_RAT	Edn2	String
EDN3_RAT	Edn3	String
EDNRA_RAT	Ednra	String
EGR2_RAT	Egr2	String
FGF7_RAT	Fgf7	String
FOXE3_RAT	Foxe3	String
AKT1_RAT	Akt1	String
ANDR_RAT	Ar	String
ARTN_RAT	Artn	String
BCL2_RAT	Bcl2	String
BMP4_RAT	Bmp4	String
CALB1_RAT	Calb1	String
CALB2_RAT	Calb2	String
CALC_RAT	Calca	String
CDK5_RAT	Cdk5	String
CNTF_RAT	Cntf	String
DHSB_RAT	Sdhb	String
DOPO_RAT	Dbh	String
ECE1_RAT	Ece1	String
EDN1_RAT	Edn1	String
EDN2_RAT	Edn2	String
EDN3_RAT	Edn3	String
EDNRA_RAT	Ednra	String
EGR2_RAT	Egr2	String
FGF7_RAT	Fgf7	String
FOXE3_RAT	Foxe3	String
GOGA5_RAT	Golga5	String
GON1_RAT	Gnrh1	String
GRP78_RAT	Hspa5	String
HGF_RAT	Hgf	String
ICAM1_RAT	Icam1	String
KSYK_RAT	Syk	String
MITF_RAT	Mitf	String
MYP0_RAT	Mpz	String
NGF_RAT	Ngf	String
NKX21_RAT	Nkx2-1	String
NTF3_RAT	Ntf3	String
NTF4_RAT	Ntf4	String
NTRK1_RAT	Ntrk1	String
NTRK2_RAT	Ntrk2	String
PDGFB_RAT	Pdgfb	String
SOLH2_RAT	Sohlh2	String
SOX10_RAT	Sox10	String
SUMO1_RAT	Sumo1	String
TY3H_RAT	Th	String
UBC9_RAT	Ube2i	String
VEGFA_RAT	Vegfa	String
WT1_RAT	Wt1	String
GOGA5_RAT	Golga5	String
GON1_RAT	Gnrh1	String
GRP78_RAT	Hspa5	String
HGF_RAT	Hgf	String
ICAM1_RAT	Icam1	String
KSYK_RAT	Syk	String
MITF_RAT	Mitf	String
MYP0_RAT	Mpz	String
NGF_RAT	Ngf	String
NKX21_RAT	Nkx2-1	String
NTF3_RAT	Ntf3	String
NTF4_RAT	Ntf4	String
NTRK1_RAT	Ntrk1	String
NTRK2_RAT	Ntrk2	String
PDGFB_RAT	Pdgfb	String
SOLH2_RAT	Sohlh2	String
SOX10_RAT	Sox10	String
SUMO1_RAT	Sumo1	String
TY3H_RAT	Th	String
UBC9_RAT	Ube2i	String
VEGFA_RAT	Vegfa	String
WT1_RAT	Wt1	String

View Microarray data

Temporarily unavailable 

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