SG ID

SG00002016 

UniProt Accession

Q6UY90_RAT;Q6UY90;  

Theoretical PI

6.29  

Molecular Weight

159258 Da  

Genbank Nucleotide ID

AY357891;  

Genbank Protein ID

AAQ67738.1; 

Gene Name

Ptch1 

Gene Synonyms/Alias

Ptch 

Protein Name

 

Protein Synonyms/Alias

SubName: PatchedSubName: Protein Ptch1 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. C. R. Morales, A. Fox, M. El-Alfy, X. Ni and W. S. Argraves (2009) Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 72(11): 809-15. 

Abstract
Desert hedgehog (Dhh) signaling plays an essential role in the normal development of the testis and in the process of spermatogenesis. Little is known about the involvement in spermatogenesis of the prototypic member of the family, Ptc1, which acts to suppress hedgehog signaling through Smoothened (Smo). Here, we have examined the expression of Ptc1, Smo, and Dhh in mouse and rat seminiferous epithelium. Our findings demonstrate that Ptc1 and Smo are expressed by primary spermatocytes and by round and condensing spermatids whereas Dhh is expressed by Sertoli cells. The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis. PMID: [19484749] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0016021	C:integral to membrane	IEA:InterPro.
GO:0030496	C:midbody	IEA:Compara.
GO:0005886	C:plasma membrane	IEA:Compara.
GO:0008158	F:hedgehog receptor activity	IEA:InterPro.
GO:0008201	F:heparin binding	IEA:Compara.
GO:0007420	P:brain development	IEA:Compara.
GO:0001658	P:branching involved in ureteric bud morphogenesis	IEA:Compara.
GO:0061005	P:cell differentiation involved in kidney development	IEA:Compara.
GO:0072203	P:cell proliferation involved in metanephros development	IEA:Compara.
GO:0021904	P:dorsal/ventral neural tube patterning	IEA:Compara.
GO:0009953	P:dorsal/ventral pattern formation	ISS:UniProtKB.
GO:0030326	P:embryonic limb morphogenesis	ISS:UniProtKB.
GO:0008544	P:epidermis development	IEA:Compara.
GO:0042593	P:glucose homeostasis	IEA:Compara.
GO:0003007	P:heart morphogenesis	IEA:Compara.
GO:0035137	P:hindlimb morphogenesis	IEA:Compara.
GO:0043616	P:keratinocyte proliferation	IEA:Compara.
GO:0060603	P:mammary gland duct morphogenesis	IEA:Compara.
GO:0060644	P:mammary gland epithelial cell differentiation	IEA:Compara.
GO:0051782	P:negative regulation of cell division	IEA:Compara.
GO:0050680	P:negative regulation of epithelial cell proliferation	IEA:Compara.
GO:0040015	P:negative regulation of multicellular organism growth	ISS:UniProtKB.
GO:0045879	P:negative regulation of smoothened signaling pathway	IEA:Compara.
GO:0021997	P:neural plate axis specification	IEA:Compara.
GO:0001843	P:neural tube closure	IEA:Compara.
GO:0009887	P:organ morphogenesis	ISS:UniProtKB.
GO:0016485	P:protein processing	ISS:UniProtKB.
GO:0007346	P:regulation of mitotic cell cycle	IEA:Compara.
GO:0032880	P:regulation of protein localization	IEA:Compara.
GO:0008589	P:regulation of smoothened signaling pathway	ISS:UniProtKB.
GO:0010157	P:response to chlorate	IEA:Compara.
GO:0007224	P:smoothened signaling pathway	ISS:UniProtKB.

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Interpro

IPR003392;    Patched.
IPR000731;    SSD.
IPR004766;    TM_rcpt_patched.
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Pfam

PF02460;    Patched;    1.
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SMART

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PROSITE

PS50156;    SSD;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 4305 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1434 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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