SG ID

SG00002034 

UniProt Accession

F1LMI3_RAT;F1LMI3;  

Theoretical PI

FRAGMENT  

Molecular Weight

84153 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Cdh3 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein Cdh3Flags: Fragment 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. K. Pospechova, M. Kopecky, P. Nachtigal, N. Pospisilova, G. Jamborova and V. Semecky (2007) Changes in the expression of P-cadherin in the normal, cryptorchid and busulphan-treated rat testis. Int J Androl 30(5): 430-8. 

Abstract
Adhesion between Sertoli cells and germ cells is important for spermatogenesis. Cadherins are Ca(2+)-dependent transmembrane proteins that mediate cell-cell adhesion. The aim of this study was to compare the expression of P-cadherin in unilaterally cryptorchid and busulphan-treated rat testes using immunohistochemistry. The pattern of expression of P-cadherin in the seminiferous epithelium changed with the stage of the seminiferous epithelium. The membranes of round spermatids and membranes and cytoplasm of spermatocytes were strongly positive. Our experiments revealed that busulphan treatment (2 doses - 10 mg/kg of body weight - 21 days apart) and cryptorchism led to destructive changes in the structure of seminiferous tubules, together with the decrease in P-cadherin expression. The expression of P-cadherin disappeared in the spermatids segregated from the epithelium while segregated spermatocytes remained still positive for P-cadherin during the 3- to 11-day cryptorchid period. In busulphan-treated animals, the expression of P-cadherin was dependent on the presence or absence of the spermatocytes and spermatids in the tubules. Strong positivity for P-cadherin was observed in the spermatocytes that re-appeared in the regenerating seminiferous epithelium. We suggest that P-cadherin participates in the architecture of adherens junctions in testis, plays an important role in maintaining normal spermatogenesis and that cryptorchism and busulphan treatment lead to adherens junction disintegration. PMID: [17298545] 

Figures for illustrating the function of this protein/gene

Function

Cadherins are calcium dependent cell adhesion proteins(By similarity). 

Subcellular Location

Membrane; Single-pass type I membraneprotein (By similarity). 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005913	C:cell-cell adherens junction	IEA:Compara.
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0005886	C:plasma membrane	IEA:UniProtKB-KW.
GO:0005509	F:calcium ion binding	IEA:InterPro.
GO:0007156	P:homophilic cell adhesion	IEA:InterPro.

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Interpro

IPR002126;    Cadherin.
IPR015919;    Cadherin-like.
IPR020894;    Cadherin_CS.
IPR000233;    Cadherin_cytoplasmic-dom.
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Pfam

PF00028;    Cadherin;    5.
PF01049;    Cadherin_C;    1.
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SMART

SM00112;    CA;    4.
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PROSITE

PS00232;    CADHERIN_1;    3.
PS50268;    CADHERIN_2;    4.
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PRINTS

PR00205;    CADHERIN.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 766 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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