SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00002042 
UniProt Accession
Theoretical PI
8.59  
Molecular Weight
44329 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Tgfb1 
Gene Synonyms/Alias
 
Protein Name
Transforming growth factor beta-1 Latency-associated peptide 
Protein Synonyms/Alias
TGF-beta-1Contains:LAPFlags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:1;80894705-80911019;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. A. Damestoy, M. H. Perrard, M. Vigier, O. Sabido and P. Durand (2005) Transforming growth factor beta-1 decreases the yield of the second meiotic division of rat pachytene spermatocytes in vitro. Reprod Biol Endocrinol 3(): 22. 

Abstract
BACKGROUND PMID: [15941479] 

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Figures for illustrating the function of this protein/gene
Ref: A. Damestoy, M. H. Perrard, M. Vigier, O. Sabido and P. Durand (2005) Transforming growth factor beta-1 decreases the yield of the second meiotic division of rat pachytene spermatocytes in vitro. Reprod Biol Endocrinol 3(): 22. PMID: [15941479]
Function
Multifunctional protein that controls proliferation,differentiation and other functions in many cell types. Many cellssynthesize TGFB1 and have specific receptors for it. It positivelyand negatively regulates many other growth factors. It plays animportant role in bone remodeling as it is a potent stimulator ofosteoblastic bone formation, causing chemotaxis, proliferation anddifferentiation in committed osteoblasts. 
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Subcellular Location
Secreted, extracellular space, extracellularmatrix (By similarity). 
Tissue Specificity
Abundant in the bone matrix. 
Gene Ontology
GO IDGO termEvidence
GO:0030424 C:axon IDA:RGD.
GO:0009986 C:cell surface IDA:BHF-UCL.
GO:0005615 C:extracellular space IDA:RGD.
GO:0005902 C:microvillus IEA:Compara.
GO:0043025 C:neuronal cell body IDA:RGD.
GO:0005634 C:nucleus ISS:UniProtKB.
GO:0005578 C:proteinaceous extracellular matrix IEA:UniProtKB-SubCell.
GO:0030141 C:secretory granule IDA:RGD.
GO:0043499 F:eukaryotic cell surface binding IEA:Compara.
GO:0002460 P:adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IEA:Compara.
GO:0007568 P:aging IEP:RGD.
GO:0006754 P:ATP biosynthetic process ISS:UniProtKB.
GO:0060751 P:branch elongation involved in mammary gland duct branching IEA:Compara.
GO:0007050 P:cell cycle arrest ISS:UniProtKB.
GO:0008219 P:cell death IEA:Compara.
GO:0016049 P:cell growth IEA:InterPro.
GO:0045216 P:cell-cell junction organization ISS:UniProtKB.
GO:0006874 P:cellular calcium ion homeostasis IEA:Compara.
GO:0071549 P:cellular response to dexamethasone stimulus IDA:UniProtKB.
GO:0071363 P:cellular response to growth factor stimulus IEA:Compara.
GO:0071407 P:cellular response to organic cyclic compound IEA:Compara.
GO:0002062 P:chondrocyte differentiation ISS:UniProtKB.
GO:0009817 P:defense response to fungus, incompatible interaction IDA:RGD.
GO:0048565 P:digestive tract development IEP:RGD.
GO:0009790 P:embryo development IEP:RGD.
GO:0007492 P:endoderm development IEA:Compara.
GO:0007173 P:epidermal growth factor receptor signaling pathway ISS:UniProtKB.
GO:0001837 P:epithelial to mesenchymal transition IDA:RGD.
GO:0019049 P:evasion or tolerance of host defenses by virus ISS:UniProtKB.
GO:0085029 P:extracellular matrix assembly IEA:Compara.
GO:0060325 P:face morphogenesis IEA:Compara.
GO:0007565 P:female pregnancy IEP:RGD.
GO:0060364 P:frontal suture morphogenesis IEP:RGD.
GO:0008354 P:germ cell migration IEA:Compara.
GO:0002244 P:hemopoietic progenitor cell differentiation ISS:UniProtKB.
GO:0030214 P:hyaluronan catabolic process IEA:Compara.
GO:0006917 P:induction of apoptosis ISS:UniProtKB.
GO:0006954 P:inflammatory response IEA:Compara.
GO:0048839 P:inner ear development IEP:RGD.
GO:0070306 P:lens fiber cell differentiation IEA:Compara.
GO:0031663 P:lipopolysaccharide-mediated signaling pathway IEA:Compara.
GO:0030324 P:lung development TAS:RGD.
GO:0048535 P:lymph node development IEA:Compara.
GO:0060744 P:mammary gland branching involved in thelarche IEA:Compara.
GO:0000165 P:MAPK cascade IEA:Compara.
GO:0031575 P:mitotic cell cycle G1/S transition checkpoint ISS:UniProtKB.
GO:0032943 P:mononuclear cell proliferation IEA:Compara.
GO:0001763 P:morphogenesis of a branching structure IDA:RGD.
GO:0042552 P:myelination IMP:RGD.
GO:0043011 P:myeloid dendritic cell differentiation IEA:Compara.
GO:0043537 P:negative regulation of blood vessel endothelial cell migration ISS:UniProtKB.
GO:0030308 P:negative regulation of cell growth ISS:UniProtKB.
GO:0022408 P:negative regulation of cell-cell adhesion ISS:UniProtKB.
GO:0008156 P:negative regulation of DNA replication ISS:UniProtKB.
GO:0050680 P:negative regulation of epithelial cell proliferation IDA:RGD.
GO:0045599 P:negative regulation of fat cell differentiation ISS:UniProtKB.
GO:1900126 P:negative regulation of hyaluronan biosynthetic process IEA:Compara.
GO:0050777 P:negative regulation of immune response IDA:RGD.
GO:0010936 P:negative regulation of macrophage cytokine production IEA:Compara.
GO:0045930 P:negative regulation of mitotic cell cycle ISS:UniProtKB.
GO:0045662 P:negative regulation of myoblast differentiation ISS:UniProtKB.
GO:0007406 P:negative regulation of neuroblast proliferation IDA:RGD.
GO:0030279 P:negative regulation of ossification IEA:Compara.
GO:0050765 P:negative regulation of phagocytosis IDA:RGD.
GO:0001933 P:negative regulation of protein phosphorylation ISS:UniProtKB.
GO:0051280 P:negative regulation of release of sequestered calcium ion into cytosol IDA:RGD.
GO:0048642 P:negative regulation of skeletal muscle tissue development ISS:UniProtKB.
GO:0042130 P:negative regulation of T cell proliferation IEA:Compara.
GO:0000122 P:negative regulation of transcription from RNA polymerase II promoter IEA:Compara.
GO:0045892 P:negative regulation of transcription, DNA-dependent ISS:UniProtKB.
GO:0031100 P:organ regeneration IMP:RGD.
GO:0043932 P:ossification involved in bone remodeling IEA:Compara.
GO:0060389 P:pathway-restricted SMAD protein phosphorylation ISS:UniProtKB.
GO:0043536 P:positive regulation of blood vessel endothelial cell migration ISS:UniProtKB.
GO:0030501 P:positive regulation of bone mineralization IEA:Compara.
GO:0090190 P:positive regulation of branching involved in ureteric bud morphogenesis IMP:UniProtKB.
GO:0071158 P:positive regulation of cell cycle arrest IEA:Compara.
GO:0051781 P:positive regulation of cell division IEA:UniProtKB-KW.
GO:0050921 P:positive regulation of chemotaxis ISS:UniProtKB.
GO:0032967 P:positive regulation of collagen biosynthetic process ISS:UniProtKB.
GO:0050679 P:positive regulation of epithelial cell proliferation IDA:RGD.
GO:0010718 P:positive regulation of epithelial to mesenchymal transition ISS:UniProtKB.
GO:0031536 P:positive regulation of exit from mitosis IDA:RGD.
GO:0010763 P:positive regulation of fibroblast migration ISS:UniProtKB.
GO:0035066 P:positive regulation of histone acetylation IEA:Compara.
GO:0031065 P:positive regulation of histone deacetylation IEA:Compara.
GO:0032740 P:positive regulation of interleukin-17 production ISS:UniProtKB.
GO:0048298 P:positive regulation of isotype switching to IgA isotypes IEA:Compara.
GO:0043406 P:positive regulation of MAP kinase activity ISS:UniProtKB.
GO:0051092 P:positive regulation of NF-kappaB transcription factor activity IDA:RGD.
GO:0042482 P:positive regulation of odontogenesis IEA:Compara.
GO:0010862 P:positive regulation of pathway-restricted SMAD protein phosphorylation ISS:UniProtKB.
GO:0033138 P:positive regulation of peptidyl-serine phosphorylation ISS:UniProtKB.
GO:0010800 P:positive regulation of peptidyl-threonine phosphorylation ISS:UniProtKB.
GO:0043552 P:positive regulation of phosphatidylinositol 3-kinase activity ISS:UniProtKB.
GO:0031334 P:positive regulation of protein complex assembly IEA:Compara.
GO:0035307 P:positive regulation of protein dephosphorylation ISS:UniProtKB.
GO:0051897 P:positive regulation of protein kinase B signaling cascade ISS:UniProtKB.
GO:0050714 P:positive regulation of protein secretion ISS:UniProtKB.
GO:0060391 P:positive regulation of SMAD protein import into nucleus IEA:Compara.
GO:0051152 P:positive regulation of smooth muscle cell differentiation IDA:MGI.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter IEA:Compara.
GO:0045893 P:positive regulation of transcription, DNA-dependent ISS:UniProtKB.
GO:0006611 P:protein export from nucleus ISS:UniProtKB.
GO:0000060 P:protein import into nucleus, translocation ISS:UniProtKB.
GO:0043491 P:protein kinase B signaling cascade IEA:Compara.
GO:0032801 P:receptor catabolic process ISS:UniProtKB.
GO:0060762 P:regulation of branching involved in mammary gland duct morphogenesis IEA:Compara.
GO:0061035 P:regulation of cartilage development IEA:Compara.
GO:0051101 P:regulation of DNA binding IEA:Compara.
GO:0002028 P:regulation of sodium ion transport IEA:Compara.
GO:0017015 P:regulation of transforming growth factor beta receptor signaling pathway ISS:UniProtKB.
GO:0045066 P:regulatory T cell differentiation IEA:Compara.
GO:0070723 P:response to cholesterol ISS:UniProtKB.
GO:0042493 P:response to drug IEP:RGD.
GO:0032355 P:response to estradiol stimulus IEP:RGD.
GO:0009749 P:response to glucose stimulus IEP:RGD.
GO:0001666 P:response to hypoxia IEP:RGD.
GO:0034616 P:response to laminar fluid shear stress IEP:RGD.
GO:0014070 P:response to organic cyclic compound IEP:RGD.
GO:0032570 P:response to progesterone stimulus ISS:UniProtKB.
GO:0009314 P:response to radiation IEP:RGD.
GO:0033280 P:response to vitamin D IEP:RGD.
GO:0007435 P:salivary gland morphogenesis IEA:Compara.
GO:0007183 P:SMAD protein complex assembly ISS:UniProtKB.
GO:0007184 P:SMAD protein import into nucleus IDA:RGD.
GO:0043029 P:T cell homeostasis IEA:Compara.
GO:0002513 P:tolerance induction to self antigen IEA:Compara.
GO:0007179 P:transforming growth factor beta receptor signaling pathway ISS:UniProtKB.
GO:0001657 P:ureteric bud development IEA:Compara.
GO:0042060 P:wound healing IMP:RGD.
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Interpro
IPR001839;    TGF-b_C.
IPR001111;    TGF-b_N.
IPR016319;    TGF-beta.
IPR015615;    TGF-beta-rel.
IPR003939;    TGFb1.
IPR017948;    TGFb_CS.
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Pfam
PF00019;    TGF_beta;    1.
PF00688;    TGFb_propeptide;    1.
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SMART
SM00204;    TGFB;    1.
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PROSITE
PS00250;    TGF_BETA_1;    1.
PS51362;    TGF_BETA_2;    1.
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PRINTS
PR01423;    TGFBETA.;   
PR01424;    TGFBETA1.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     29       By similarity.
CHAIN        30    278       Latency-associated peptide.
                             /FTId=PRO_0000033770.
CHAIN       279    390       Transforming growth factor beta-1.
                             /FTId=PRO_0000033771.
REGION       30     74       Straightjacket domain (By similarity).
REGION       75    271       Arm domain (By similarity).
MOTIF       244    246       Cell attachment site (Potential).
CARBOHYD     82     82       N-linked (GlcNAc...) (By similarity).
CARBOHYD    136    136       N-linked (GlcNAc...) (By similarity).
CARBOHYD    176    176       N-linked (GlcNAc...) (By similarity).
DISULFID     33     33       Interchain (with C-1350 or C-1375 in
                             LTBP1); in inactive form (By similarity).
DISULFID    223    223       Interchain (with C-225) (By similarity).
DISULFID    225    225       Interchain (with C-223) (By similarity).
DISULFID    285    294       By similarity.
DISULFID    293    356       By similarity.
DISULFID    322    387       By similarity.
DISULFID    326    389       By similarity.
DISULFID    355    355       Interchain (By similarity).
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Nucleotide Sequence
Length: 1585 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 390 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Tgfbr3DIP 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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