1. Y. Jia, K. W. Lee, R. Swerdloff, D. Hwang, L. J. Cobb, A. Sinha Hikim, Y. H. Lue, P. Cohen and C. Wang (2010) Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. J Biol Chem 285(3): 1726-32.
Abstract Germ cell apoptosis is crucial for spermatogenesis and can be triggered by various stimuli, including intratesticular hormone deprivation. This study proposes a role for insulin-like growth factor binding protein-3 (IGFBP-3) in male germ cell apoptosis. Groups of adult Sprague-Dawley male rats received one of the following treatments for 5 days PMID: [19887447]