SG ID

SG00002073 

UniProt Accession

Q6AYN5_RAT;Q6AYN5;  

Theoretical PI

9.48  

Molecular Weight

25566 Da  

Genbank Nucleotide ID

BC078976; CH473971; CH473971; CH473971; CH473971; CH473971;  

Genbank Protein ID

AAH78976.1; EDM14781.1; EDM14783.1; EDM14784.1; EDM14785.1; EDM14786.1; 

Gene Name

Stard6 

Gene Synonyms/Alias

ORFNames=rCG_46848 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein Stard6SubName: STAR-related lipid transfer (START) domain containing protein 6, isoform CRA_aSubName: StAR-related lipid transfer (START) domain containing 6 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. C. Gomes, S. D. Oh, J. W. Kim, S. Y. Chun, K. Lee, H. B. Kwon and J. Soh (2005) Expression of the putative sterol binding protein Stard6 gene is male germ cell specific. Biol Reprod 72(3): 651-8. 

Abstract
Mammalian spermatogenesis is orchestrated by many specific molecular and cellular events. To understand the detailed mechanism by which spermatogenesis is controlled, the specific genes involved in this process must be identified and studied. From the subtracted cDNA library of rat testis prepared using the representational difference analysis (RDA) method, we isolated the cDNA clone of steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) protein 6 (Stard6). Stard6 cDNA consists of 1146 base pairs of nucleotides and has the longest open reading frame, of 227 amino acids. Northern blot analysis revealed Stard6 mRNA to be testis-specific. The mRNA transcript appeared from the third week of postnatal development, and the expression level increased up to adulthood. Moreover, in situ hybridization showed Stard6 mRNA expression to be germ cell-specific and expressed only during the maturation stages of round and elongated spermatids of adult rat testis. Western blot analysis with Stard6 antibody revealed a 28-kDa Stard6 protein only in testis. Immunohistochemistry further confirmed localization of Stard6 protein expressed in mature germ cells, in concert with the in situ hybridization result. Taken together, these results suggest that Stard6, a member of the START protein family, may play a role during germ cell maturation in adult rat testis. PMID: [15564601] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID

GO term

Evidence

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Interpro

IPR023393;    START-like_dom.
IPR002913;    START_lipid-bd.
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Pfam

PF01852;    START;    1.
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SMART

SM00234;    START;    1.
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PROSITE

PS50848;    START;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1297 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 227 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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