SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00002078 
UniProt Accession
Theoretical PI
9.7  
Molecular Weight
20636 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Adm 
Gene Synonyms/Alias
 
Protein Name
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide 
Protein Synonyms/Alias
Contains:AMContains: ProAM N-terminal 20 peptide;PAMPProAM-N20Flags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:1;168380255-168382426;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. Y. F. Chan, F. Tang and W. S. O (2008) Adrenomedullin in the rat testis. II. Biol Reprod 78(4): 780-5. 

Abstract
The present study demonstrates the expression of adrenomedullin (ADM) in the rat Sertoli cells and its effect on inhibin production. The regulation of ADM by FSH and its interaction with endothelin 1 (EDN1) in the rat Sertoli cells have also been established. Primary culture of Sertoli cells secreted 414+/-27 pg immunoreactive ADM per 10(6) cells in 24 h and expressed Adm mRNA. In addition, the Sertoli cell was shown to co-express mRNAs encoding for the calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying proteins (RAMPs) 1-3. These may account for the specific binding of ADM to the Sertoli cells. Administration of ADM to Sertoli cells resulted in an enhancement of basal and FSH-stimulated inhibin B production. On the other hand, the production of ADM and the mRNA levels of Calcrl and Ramp2 in the Sertoli cells were suppressed by FSH. The results suggest that ADM, via its control in the secretion of inhibin B, may play a role in regulating spermatogenesis as well as the hypothalamus-pituitary-gonad feedback system. In addition, like in the Leydig cell, ADM and EDN1 were found to regulate the production of each other in opposite directions in the Sertoli cells, suggesting the presence of yet another local regulatory mechanism in the rat testis that may be important in modulating testicular functions regulated by gonadotropins. PMID: [18094364] 

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Figures for illustrating the function of this protein/gene
Function
AM and PAMP are potent hypotensive and vasodilatatoragents. 
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Subcellular Location
Secreted. 
Tissue Specificity
Expressed in adrenal glands, lung, kidney,heart, spleen, duodenum and submandibular glands. 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IEA:Compara.
GO:0005615 C:extracellular space IDA:RGD.
GO:0007568 P:aging IEP:RGD.
GO:0008209 P:androgen metabolic process IDA:RGD.
GO:0060670 P:branching involved in labyrinthine layer morphogenesis IEA:Compara.
GO:0006171 P:cAMP biosynthetic process IEA:Compara.
GO:0019933 P:cAMP-mediated signaling IEP:RGD.
GO:0048589 P:developmental growth IEA:Compara.
GO:0007204 P:elevation of cytosolic calcium ion concentration IDA:RGD.
GO:0007565 P:female pregnancy IEP:RGD.
GO:0002031 P:G-protein coupled receptor internalization IEA:Compara.
GO:0007507 P:heart development IEA:Compara.
GO:0046879 P:hormone secretion IMP:RGD.
GO:0008285 P:negative regulation of cell proliferation IMP:RGD.
GO:0043116 P:negative regulation of vascular permeability IEA:Compara.
GO:0045906 P:negative regulation of vasoconstriction IEA:Compara.
GO:0001843 P:neural tube closure IEA:Compara.
GO:0031102 P:neuron projection regeneration IMP:RGD.
GO:0042475 P:odontogenesis of dentin-containing tooth IEP:RGD.
GO:0031100 P:organ regeneration IEP:RGD.
GO:0045766 P:positive regulation of angiogenesis IEA:Compara.
GO:0045768 P:positive regulation of anti-apoptosis IMP:RGD.
GO:0030819 P:positive regulation of cAMP biosynthetic process IEA:Compara.
GO:0008284 P:positive regulation of cell proliferation IEA:Compara.
GO:0010460 P:positive regulation of heart rate IDA:RGD.
GO:2001214 P:positive regulation of vasculogenesis IEA:Compara.
GO:0045909 P:positive regulation of vasodilation IMP:RGD.
GO:0002026 P:regulation of the force of heart contraction IDA:RGD.
GO:0009409 P:response to cold IEP:RGD.
GO:0051384 P:response to glucocorticoid stimulus IEP:RGD.
GO:0001666 P:response to hypoxia IEP:RGD.
GO:0032868 P:response to insulin stimulus IEP:RGD.
GO:0032496 P:response to lipopolysaccharide IMP:RGD.
GO:0042594 P:response to starvation IEP:RGD.
GO:0009611 P:response to wounding IDA:RGD.
GO:0060712 P:spongiotrophoblast layer development IEA:Compara.
GO:0097084 P:vascular smooth muscle cell development IEA:Compara.
GO:0001570 P:vasculogenesis IEA:Compara.
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Interpro
IPR001710;    Adrenomedullin.
IPR021116;    Procalcitonin/adrenomedullin.
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Pfam
PF00214;    Calc_CGRP_IAPP;    1.
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SMART
PROSITE
PRINTS
PR00801;    ADRENOMEDULN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     21       By similarity.
PEPTIDE      22     41       Proadrenomedullin N-20 terminal peptide.
                             /FTId=PRO_0000000973.
PROPEP       45     91       By similarity.
                             /FTId=PRO_0000000974.
PEPTIDE      94    143       Adrenomedullin.
                             /FTId=PRO_0000000975.
PROPEP      149    185       PreproAM C-terminal fragment (By
                             similarity).
                             /FTId=PRO_0000000976.
MOD_RES      41     41       Arginine amide (By similarity).
MOD_RES     143    143       Tyrosine amide (By similarity).
DISULFID    107    112       By similarity.
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Nucleotide Sequence
Length: 1376 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 185 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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