SG ID

SG00002095 

UniProt Accession

F1M959_RAT;F1M959;  

Theoretical PI

5.68  

Molecular Weight

124053 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Egf 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Pro-epidermal growth factor 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. Y. C. Yan, Y. P. Sun and M. L. Zhang (1998) Testis epidermal growth factor and spermatogenesis. Arch Androl 40(2): 133-46. 

Abstract
Epidermal growth factor (EGF) is a cytokine that promotes cell proliferation, regulates tissue differentiation, and modulates organogenesis. Although a rich source of EGF is the submaxillary gland, many tissues produce this cytokine, including the testis. Leydig cells are the principal source of EGF in the testis. On attainment of sexual maturation the germ cells, primarily spermatocytes and round spermatids, form EGF with the onset of spermatogenesis. EGF appears to be involved in the development of the testis and in spermatogenesis. The expression of the EGF gene in rat testis was determined by the application of the RT-PCR method and testis RNA as substrate. The results suggest that EGF produced by Leydig cells and germ cells may modulate spermatogenesis as an autocrine and/or paracrine factor. PMID: [9507746] 

2. S. Kurokawa, Y. Kojima, K. Mizuno, A. Nakane, Y. Hayashi and K. Kohri (2005) Effect of epidermal growth factor on spermatogenesis in the cryptorchid rat. J Urol 174(6): 2415-9. 

Abstract
PURPOSE PMID: [16280859] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005615	C:extracellular space	IEA:Compara.
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0005886	C:plasma membrane	IEA:Compara.
GO:0005509	F:calcium ion binding	IEA:InterPro.
GO:0000186	P:activation of MAPKK activity	IEA:Compara.
GO:0001525	P:angiogenesis	IEA:Compara.
GO:0048754	P:branching morphogenesis of a tube	IEA:Compara.
GO:0007173	P:epidermal growth factor receptor signaling pathway	IEA:Compara.
GO:0070371	P:ERK1 and ERK2 cascade	IEA:Compara.
GO:0060749	P:mammary gland alveolus development	IEA:Compara.
GO:0090370	P:negative regulation of cholesterol efflux	IEA:Compara.
GO:0051048	P:negative regulation of secretion	IEA:Compara.
GO:0018108	P:peptidyl-tyrosine phosphorylation	IEA:Compara.
GO:0035413	P:positive regulation of catenin import into nucleus	IEA:Compara.
GO:0021940	P:positive regulation of cerebellar granule cell precursor proliferation	IEA:Compara.
GO:0043388	P:positive regulation of DNA binding	IEA:Compara.
GO:0045741	P:positive regulation of epidermal growth factor-activated receptor activity	IEA:Compara.
GO:1900127	P:positive regulation of hyaluronan biosynthetic process	IEA:Compara.
GO:0043406	P:positive regulation of MAP kinase activity	IEA:Compara.
GO:0045840	P:positive regulation of mitosis	IEA:Compara.
GO:0010800	P:positive regulation of peptidyl-threonine phosphorylation	IEA:Compara.
GO:2000060	P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IEA:Compara.
GO:0045893	P:positive regulation of transcription, DNA-dependent	IEA:Compara.
GO:0090279	P:regulation of calcium ion import	IEA:Compara.
GO:2000008	P:regulation of protein localization at cell surface	IEA:Compara.
GO:0007262	P:STAT protein import into nucleus	IEA:Compara.

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Interpro

IPR011042;    6-blade_b-propeller_TolB-like.
IPR000742;    EG-like_dom.
IPR006210;    EGF-like.
IPR001881;    EGF-like_Ca-bd.
IPR013032;    EGF-like_CS.
IPR000152;    EGF-type_Asp/Asn_hydroxyl_site.
IPR018097;    EGF_Ca-bd_CS.
IPR000033;    LDLR_classB_rpt.
IPR016317;    Pro-epidermal_GF.
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Pfam

PF07645;    EGF_CA;    3.
PF00058;    Ldl_recept_b;    4.
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SMART

SM00181;    EGF;    6.
SM00179;    EGF_CA;    2.
SM00135;    LY;    8.
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PROSITE

PS00010;    ASX_HYDROXYL;    3.
PS00022;    EGF_1;    1.
PS01186;    EGF_2;    7.
PS50026;    EGF_3;    5.
PS01187;    EGF_CA;    3.
PS51120;    LDLRB;    9.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1133 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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