SG ID

SG00002101 

UniProt Accession

F1M9Q2_RAT;F1M9Q2;  

Theoretical PI

9.3  

Molecular Weight

75498 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Abcc9 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: ATP-binding cassette sub-family C member 9 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. M. Zhou, H. J. He, O. Tanaka, M. Sekiguchi, K. Kawahara and H. Abe (2011) Different localization of ATP sensitive K+ channel subunits in rat testis. Anat Rec (Hoboken) 294(4): 729-37. 

Abstract
ATP sensitive K(+) (K(ATP) ) channels are important linkage of cell membrane excitability to its cellular bioenergetic state. These channels are composed of pore-forming subunits and regulatory subunits. The present study focused on the cellular expressions and localizations of these subunits in rat testis. RT-PCR analysis showed that rat testis contained five K(ATP) channel subunits, Kir6.1, Kir6.2, SUR1, SUR2A and SUR2B. Immunoblot assay showed that proteins of Kir6.1, Kir6.2, SUR2A and SUR2B were expressed in rat testis. Immunohistochemistry revealed these K(ATP) channel subunits were positive in different localizations of spermatogenic cells, Sertoli cells and Leydig cells, which implies these subunits playing important roles in spermatogenesis. Co-localization of Kir6.2 with SUR2B was determined in acrosome or head cap of spermatids by double immunofluorescence analysis by indicating K(ATP) channel might be formed by Kir6.2 and SUR2B in acrosome of spermatids. Different localizations of the K(ATP) channel subunits in the cell membrane and membranous organelles of spermatogenic cells and Sertoli cells indicated the complex and multiple functions of K(ATP) channels in rat testis. PMID: [21328565] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0016021	C:integral to membrane	IEA:InterPro.
GO:0005524	F:ATP binding	IEA:InterPro.
GO:0042626	F:ATPase activity, coupled to transmembrane movement of substances	IEA:InterPro.
GO:0008281	F:sulfonylurea receptor activity	IEA:InterPro.
GO:0006813	P:potassium ion transport	IEA:InterPro.

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Interpro

IPR017940;    ABC_transporter_type1.
IPR001140;    ABC_transptr_TM_dom.
IPR011527;    ABC_transptrTM_dom_typ1.
IPR001475;    Sulphonylurea_rcpt-2.
IPR000388;    Sulphorea_rcpt.
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Pfam

PF00664;    ABC_membrane;    1.
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SMART

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PROSITE

PS50929;    ABC_TM1F;    1.
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PRINTS

PR01094;    SULFNYLUR2.;   
PR01092;    SULFNYLUREAR.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 669 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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