SG ID

SG00002124 

UniProt Accession

A3EX84_PIG;A3EX84;  

Theoretical PI

8.78  

Molecular Weight

27215 Da  

Genbank Nucleotide ID

CU467727; CU855754; EF053388;  

Genbank Protein ID

ABN15099.1; 

Gene Name

LGALS3 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Lectin galactoside-binding soluble 3SubName: Uncharacterized protein 

Sus scrofa (Pig) 

9823 

Temporarily unavailable 

The information of related literatures

1. C. Deschildre, J. W. Ji, S. Chater, F. Dacheux, J. Selva, M. Albert, M. Bailly, F. Hatey and M. Benahmed (2007) Expression of galectin-3 and its regulation in the testes. Int J Androl 30(1): 28-40. 

Abstract
Although spermatogenesis is a complex process under hormonal control, which includes mainly follicle stimulating hormone (FSH) and androgens, little is known about the intra-testicular mediators of these hormones. In the present study, galectin-3 (Gal-3) expression has been identified in human, rat and porcine testes where it is under hormonal control. Gal-3 is present in Sertoli cells and appears to be absent in human and (probably) in rat germ cells. Gal-3 expression was evidenced in the testes, in terms of both mRNA and protein (31 kDa). Gal-3 expression in cultured porcine Sertoli cells was shown to be under the positive control of FSH as well as of two cytokines epidermal growth factor (EGF) and tumour necrosis factor-alpha (TNF-alpha). Gal-3 expression in Sertoli cells is also potentially under the control of mature germ cells as an increased expression was observed in adult rat testes depleted in spermatocytes or spermatids. Although the function of testicular Gal-3 remains to be investigated, a potential role of Gal-3 in germ cell survival/regeneration is suggested based on its increased expression 1 month after a transient germ cell death process triggered by 10 days of treatment with the antiandrogen flutamide. Finally, although in the normal human testes, Gal-3 is exclusively located in the Sertoli cell cytoplasm, a nuclear localization is observed in the infertile testes. Together, the present findings have shown that (i) Gal-3 is expressed in the porcine, rat and human Sertoli cells; (ii) Gal-3 is under the positive control of FSH as well as of EGF and TNF-alpha and possibly of adult germ cells. These observations are compatible with a potential pro-survival role of Gal-3 in the testes. PMID: [17132155] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005743	C:mitochondrial inner membrane	IEA:Compara.
GO:0005634	C:nucleus	IEA:Compara.
GO:0005578	C:proteinaceous extracellular matrix	IEA:Compara.
GO:0030246	F:carbohydrate binding	IEA:InterPro.
GO:0030198	P:extracellular matrix organization	IEA:Compara.
GO:0001501	P:skeletal system development	IEA:Compara.

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Interpro

IPR008985;    ConA-like_lec_gl.
IPR013320;    ConA-like_subgrp.
IPR015534;    Galectin_3.
IPR001079;    Galectin_CRD.
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Pfam

PF00337;    Gal-bind_lectin;    1.
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SMART

SM00908;    Gal-bind_lectin;    1.
SM00276;    GLECT;    1.
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PROSITE

PS51304;    GALECTIN;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 260 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

Temporarily unavailable 

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