SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00002128 
UniProt Accession
Theoretical PI
4.31  
Molecular Weight
33669 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
SPP1 
Gene Synonyms/Alias
OPN 
Protein Name
Osteopontin 
Protein Synonyms/Alias
Bone sialoprotein 1; Secreted phosphoprotein 1;SPP-1Flags: Precursor 
Organism
Sus scrofa (Pig) 
NCBI Taxonomy ID
9823 
Chromosome Location
chr:8;112396255-112600779;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. S. Kim and T. Shin (2007) Immunohistochemical study of osteopontin in boar testis. J Vet Sci 8(2): 107-10. 

Abstract
The expression of osteopontin (OPN) in boar testis was studied. Western blot analysis detected 66- and 32-kDa OPN immunopositive bands in the testes of adult boars. In postnatal piglets, the 66-kDa OPN band was detected in the testes, but not the 32-kDa band. In the newborn testis, OPN immunostaining was seen in gonocytes and in some supporting cells in the seminiferous tubules, as well as in interstitial Leydig cells. In the adult boar testis, OPN immunoreactivity was detected in seminiferous tubules with varying intensities. Intense OPN immunostaining was seen in the residual bodies and acrosomes in the spermatids while, occasionally, OPN immunostaining was seen in spermatogonia and various stage of spermatocytes but in few Sertoli cells in the seminiferous tubules. In addition, Leydig cells in adult boars were weakly immunostained with OPN. These findings suggest that OPN is detected in the majority of germ cells and is involved in spermatogenesis in boar testis. PMID: [17519561] 

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Figures for illustrating the function of this protein/gene
Function
Acts as a cytokine involved in enhancing production ofinterferon-gamma and interleukin-12 and reducing production ofinterleukin-10 and is essential in the pathway that leads to typeI immunity (By similarity). 
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Subcellular Location
Secreted. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0045177 C:apical part of cell IEA:Compara.
GO:0005737 C:cytoplasm IEA:Compara.
GO:0005615 C:extracellular space IEA:UniProtKB-KW.
GO:0050840 F:extracellular matrix binding IEA:Compara.
GO:0031214 P:biomineral tissue development IEA:UniProtKB-KW.
GO:0007155 P:cell adhesion IEA:UniProtKB-KW.
GO:0030593 P:neutrophil chemotaxis IEA:Compara.
GO:0001503 P:ossification IEA:InterPro.
GO:0010811 P:positive regulation of cell-substrate adhesion IEA:Compara.
GO:0033280 P:response to vitamin D IEA:Compara.
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Interpro
IPR002038;    Osteopontin.
IPR019841;    Osteopontin_CS.
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Pfam
PF00865;    Osteopontin;    1.
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SMART
SM00017;    OSTEO;    1.
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PROSITE
PS00884;    OSTEOPONTIN;    1.
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PRINTS
PR00216;    OSTEOPONTIN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     16       Potential.
CHAIN        17    303       Osteopontin.
                             /FTId=PRO_0000020323.
MOTIF       154    156       Cell attachment site.
MOD_RES      24     24       Phosphoserine (By similarity).
MOD_RES      26     26       Phosphoserine (By similarity).
MOD_RES      27     27       Phosphoserine (By similarity).
MOD_RES      62     62       Phosphoserine (By similarity).
MOD_RES      63     63       Phosphoserine (By similarity).
MOD_RES      66     66       Phosphothreonine (By similarity).
MOD_RES      76     76       Phosphoserine (By similarity).
MOD_RES      81     81       Phosphoserine (By similarity).
MOD_RES      99     99       Phosphoserine (By similarity).
MOD_RES     104    104       Phosphoserine (By similarity).
MOD_RES     116    116       Phosphoserine (By similarity).
MOD_RES     119    119       Phosphoserine (By similarity).
MOD_RES     122    122       Phosphoserine (By similarity).
MOD_RES     125    125       Phosphoserine (By similarity).
MOD_RES     180    180       Phosphothreonine (By similarity).
MOD_RES     186    186       Phosphoserine (By similarity).
MOD_RES     190    190       Phosphoserine (By similarity).
MOD_RES     210    210       Phosphoserine (By similarity).
MOD_RES     214    214       Phosphoserine (By similarity).
MOD_RES     219    219       Phosphoserine (By similarity).
MOD_RES     223    223       Phosphoserine (By similarity).
MOD_RES     229    229       Phosphoserine (By similarity).
MOD_RES     249    249       Phosphoserine (By similarity).
MOD_RES     258    258       Phosphoserine (By similarity).
MOD_RES     270    270       Phosphoserine (By similarity).
MOD_RES     292    292       Phosphoserine (By similarity).
MOD_RES     297    297       Phosphoserine (By similarity).
MOD_RES     299    299       Phosphoserine (By similarity).
CARBOHYD     79     79       N-linked (GlcNAc...) (Potential).
CARBOHYD    130    130       O-linked (GalNAc...) (By similarity).
CARBOHYD    134    134       O-linked (GalNAc...) (By similarity).
CARBOHYD    139    139       O-linked (GalNAc...) (By similarity).
CARBOHYD    142    142       O-linked (GalNAc...) (By similarity).
CARBOHYD    147    147       O-linked (GalNAc...) (By similarity).
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Nucleotide Sequence
Length: 1430 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 303 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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