SG ID

SG00002132 

UniProt Accession

F1SSJ3_PIG;F1SSJ3;  

Theoretical PI

7.9  

Molecular Weight

128679 Da  

Genbank Nucleotide ID

FP312819;  

Genbank Protein ID

 

Gene Name

NOS 

Gene Synonyms/Alias

 

Protein Name

Nitric oxide synthase 

Protein Synonyms/Alias

EC=1.14.13.39Flags: Fragment 

Sus scrofa (Pig) 

9823 

Temporarily unavailable 

The information of related literatures

1. H. C. Kim, J. S. Byun, T. K. Lee, C. W. Jeong, M. Ahn and T. Shin (2007) Expression of nitric oxide synthase isoforms in the testes of pigs. Anat Histol Embryol 36(2): 135-8. 

Abstract
This study examined the expression of three isoforms of nitric oxide synthase (NOS) in the testes of pigs. Immunohistochemical studies demonstrated the presence of nNOS, eNOS and iNOS in interstitial cells, primary spermatocytes and spermatids. Positive immunoreactions for eNOS and iNOS were detected in peritubular myoid cells. Some vascular endothelial cells were positive for nNOS and eNOS. The expression of nitrotyrosine was detected in interstitial cells. In addition, the histochemical study revealed that all the interstitial cells were stained positively for NADPH-diaphorase, although some spermatids and vascular endothelial cells displayed moderate enzymatic activity. These findings suggest that three isoforms of NOS are expressed in the testis of pig and that they play important roles in the biology of interstitial cells that produce testosterone, as well as in spermatogenesis in the seminiferous tubules. PMID: [17371387] 

Figures for illustrating the function of this protein/gene

Function

Produces nitric oxide (NO) (By similarity). 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005901	C:caveola	IEA:Compara.
GO:0005737	C:cytoplasm	IEA:Compara.
GO:0005634	C:nucleus	IEA:Compara.
GO:0034618	F:arginine binding	IEA:Compara.
GO:0050660	F:flavin adenine dinucleotide binding	IEA:InterPro.
GO:0010181	F:FMN binding	IEA:InterPro.
GO:0020037	F:heme binding	IEA:InterPro.
GO:0050661	F:NADP binding	IEA:InterPro.
GO:0004517	F:nitric-oxide synthase activity	IEA:EC.
GO:0034617	F:tetrahydrobiopterin binding	IEA:Compara.
GO:0001525	P:angiogenesis	IEA:Compara.
GO:0006527	P:arginine catabolic process	IEA:Compara.
GO:0001974	P:blood vessel remodeling	IEA:Compara.
GO:0043542	P:endothelial cell migration	IEA:Compara.
GO:0001701	P:in utero embryonic development	IEA:Compara.
GO:0031663	P:lipopolysaccharide-mediated signaling pathway	IEA:Compara.
GO:0030324	P:lung development	IEA:Compara.
GO:0051926	P:negative regulation of calcium ion transport	IEA:Compara.
GO:0008285	P:negative regulation of cell proliferation	IEA:Compara.
GO:0051346	P:negative regulation of hydrolase activity	IEA:Compara.
GO:0014740	P:negative regulation of muscle hyperplasia	IEA:Compara.
GO:0043267	P:negative regulation of potassium ion transport	IEA:Compara.
GO:0006809	P:nitric oxide biosynthetic process	IEA:Compara.
GO:0001542	P:ovulation from ovarian follicle	IEA:Compara.
GO:0045766	P:positive regulation of angiogenesis	IEA:Compara.
GO:0050880	P:regulation of blood vessel size	IEA:Compara.
GO:0002028	P:regulation of sodium ion transport	IEA:Compara.
GO:0003100	P:regulation of systemic arterial blood pressure by endothelin	IEA:Compara.
GO:0034405	P:response to fluid shear stress	IEA:Compara.
GO:0014806	P:smooth muscle hyperplasia	IEA:Compara.

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Interpro

IPR003097;    FAD-binding_1.
IPR017927;    Fd_Rdtase_FAD-bd.
IPR001094;    Flavdoxin.
IPR008254;    Flavodoxin/NO_synth.
IPR001709;    Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR023173;    NADPH_Cyt_P450_Rdtase_dom3.
IPR004030;    NO_synthase_oxygenase_dom.
IPR026009;    NOS.
IPR012144;    NOS_met.
IPR001433;    OxRdtase_FAD/NAD-bd.
IPR017938;    Riboflavin_synthase-like_b-brl.
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Pfam

PF00667;    FAD_binding_1;    1.
PF00258;    Flavodoxin_1;    1.
PF00175;    NAD_binding_1;    1.
PF02898;    NO_synthase;    1.
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SMART

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PROSITE

PS51384;    FAD_FR;    1.
PS50902;    FLAVODOXIN_LIKE;    1.
PS60001;    NOS;    1.
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PRINTS

PR00369;    FLAVODOXIN.;   
PR00371;    FPNCR.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1155 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

Temporarily unavailable 

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