SG ID

SG00002133 

UniProt Accession

F1RJ30_PIG;F1RJ30;  

Theoretical PI

7.71  

Molecular Weight

131313 Da  

Genbank Nucleotide ID

CU972495;  

Genbank Protein ID

 

Gene Name

NOS2 

Gene Synonyms/Alias

 

Protein Name

Nitric oxide synthase 

Protein Synonyms/Alias

EC=1.14.13.39 

Sus scrofa (Pig) 

9823 

Temporarily unavailable 

The information of related literatures

1. H. C. Kim, J. S. Byun, T. K. Lee, C. W. Jeong, M. Ahn and T. Shin (2007) Expression of nitric oxide synthase isoforms in the testes of pigs. Anat Histol Embryol 36(2): 135-8. 

Abstract
This study examined the expression of three isoforms of nitric oxide synthase (NOS) in the testes of pigs. Immunohistochemical studies demonstrated the presence of nNOS, eNOS and iNOS in interstitial cells, primary spermatocytes and spermatids. Positive immunoreactions for eNOS and iNOS were detected in peritubular myoid cells. Some vascular endothelial cells were positive for nNOS and eNOS. The expression of nitrotyrosine was detected in interstitial cells. In addition, the histochemical study revealed that all the interstitial cells were stained positively for NADPH-diaphorase, although some spermatids and vascular endothelial cells displayed moderate enzymatic activity. These findings suggest that three isoforms of NOS are expressed in the testis of pig and that they play important roles in the biology of interstitial cells that produce testosterone, as well as in spermatogenesis in the seminiferous tubules. PMID: [17371387] 

Figures for illustrating the function of this protein/gene

Function

Produces nitric oxide (NO) (By similarity). 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0030863	C:cortical cytoskeleton	IEA:Compara.
GO:0005829	C:cytosol	IEA:Compara.
GO:0048471	C:perinuclear region of cytoplasm	IEA:Compara.
GO:0005777	C:peroxisome	IEA:Compara.
GO:0034618	F:arginine binding	IEA:Compara.
GO:0050660	F:flavin adenine dinucleotide binding	IEA:Compara.
GO:0010181	F:FMN binding	IEA:Compara.
GO:0020037	F:heme binding	IEA:Compara.
GO:0050661	F:NADP binding	IEA:InterPro.
GO:0004517	F:nitric-oxide synthase activity	IEA:EC.
GO:0034617	F:tetrahydrobiopterin binding	IEA:Compara.
GO:0006527	P:arginine catabolic process	IEA:Compara.
GO:0071346	P:cellular response to interferon-gamma	IEA:Compara.
GO:0071222	P:cellular response to lipopolysaccharide	IEA:Compara.
GO:0042742	P:defense response to bacterium	IEA:Compara.
GO:0010629	P:negative regulation of gene expression	IEA:Compara.
GO:0042177	P:negative regulation of protein catabolic process	IEA:Compara.
GO:0006809	P:nitric oxide biosynthetic process	IEA:Compara.
GO:0018119	P:peptidyl-cysteine S-nitrosylation	IEA:Compara.
GO:0051712	P:positive regulation of killing of cells of other organism	IEA:Compara.
GO:0042127	P:regulation of cell proliferation	IEA:Compara.
GO:0050796	P:regulation of insulin secretion	IEA:Compara.
GO:0001666	P:response to hypoxia	IEA:Compara.
GO:0006801	P:superoxide metabolic process	IEA:Compara.

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Interpro

IPR003097;    FAD-binding_1.
IPR017927;    Fd_Rdtase_FAD-bd.
IPR001094;    Flavdoxin.
IPR008254;    Flavodoxin/NO_synth.
IPR001709;    Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR023173;    NADPH_Cyt_P450_Rdtase_dom3.
IPR004030;    NO_synthase_oxygenase_dom.
IPR026009;    NOS.
IPR012144;    NOS_met.
IPR001433;    OxRdtase_FAD/NAD-bd.
IPR017938;    Riboflavin_synthase-like_b-brl.
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Pfam

PF00667;    FAD_binding_1;    1.
PF00258;    Flavodoxin_1;    1.
PF00175;    NAD_binding_1;    1.
PF02898;    NO_synthase;    1.
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SMART

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PROSITE

PS51384;    FAD_FR;    1.
PS50902;    FLAVODOXIN_LIKE;    1.
PS60001;    NOS;    1.
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PRINTS

PR00369;    FLAVODOXIN.;   
PR00371;    FPNCR.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1157 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

Temporarily unavailable 

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