Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
49199 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Hnrph, Hnrph1 
Protein Name
Heterogeneous nuclear ribonucleoprotein H Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 
Protein Synonyms/Alias
hnRNP HContains: 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

2. A major goal of the Alliance for Cellular Signaling is to elaborate the components of signal transduction networks in model cell systems, including murine B lymphocytes. Due to the importance of protein phosphorylation in many aspects of cell signaling, the initial efforts have focused on the identification of phosphorylated proteins. In order to identify serine- and threonine-phosphorylated proteins on a proteome-wide basis, WEHI-231 cells were treated with calyculin A, a serine/threonine phosphatase inhibitor, to induce high levels of protein phosphorylation. Proteins were extracted from whole-cell lysates and digested with trypsin. Phosphorylated peptides were then enriched using immobilized metal affinity chromatography and identified by liquid chromatography-tandem mass spectrometry. A total of 107 proteins and 193 phosphorylation sites were identified using these methods. Forty-two of these proteins have been reported to be phosphorylated, but only some of them have been detected in B cells. Fifty-four of the identified proteins were not previously known to be phosphorylated. The remaining 11 phosphoproteins have previously only been characterized as novel cDNA or genomic sequences. Many of the identified proteins were phosphorylated at multiple sites. The proteins identified in this study significantly expand the repertoire of proteins known to be phosphorylated in B cells. The number of newly identified phosphoproteins indicates that B cell signaling pathways utilizing protein phosphorylation are likely to be more complex than previously appreciated. PMID: [14729942] 

3. We used on-line electron capture dissociation (ECD) for the large scale identification and localization of sites of phosphorylation. Each FT-ICR ECD event was paired with a linear ion trap collision-induced dissociation (CID) event, allowing a direct comparison of the relative merits of ECD and CID for phosphopeptide identification and site localization. Linear ion trap CID was shown to be most efficient for phosphopeptide identification, whereas FT-ICR ECD was superior for localization of sites of phosphorylation. The combination of confident CID and ECD identification and confident CID and ECD localization is particularly valuable in cases where a phosphopeptide is identified just once within a phosphoproteomics experiment. PMID: [19131326] 

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This protein is a component of the heterogeneous nuclearribonucleoprotein (hnRNP) complexes which provide the substratefor the processing events that pre-mRNAs undergo before becomingfunctional, translatable mRNAs in the cytoplasm. Mediates pre-mRNAalternative splicing regulation. Inhibits, together with CUGBP1,insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.Binds to the IR RNA. Binds poly(RG) (By similarity). 
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Subcellular Location
Nucleus, nucleoplasm (By similarity). 
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0005654 C:nucleoplasm IEA:UniProtKB-SubCell.
GO:0005681 C:spliceosomal complex IEA:UniProtKB-KW.
GO:0000166 F:nucleotide binding IEA:InterPro.
GO:0003723 F:RNA binding ISS:UniProtKB.
GO:0006397 P:mRNA processing IEA:UniProtKB-KW.
GO:0043484 P:regulation of RNA splicing ISS:UniProtKB.
GO:0008380 P:RNA splicing IEA:UniProtKB-KW.
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IPR012677;    Nucleotide-bd_a/b_plait.
IPR000504;    RRM_dom.
IPR012996;    Znf_CHHC.
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PF08080;    zf-RNPHF;    1.
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SM00360;    RRM;    3.
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PS50102;    RRM;    3.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    449       Heterogeneous nuclear ribonucleoprotein
INIT_MET      1      1       Removed; alternate (By similarity).
CHAIN         2    449       Heterogeneous nuclear ribonucleoprotein
                             H, N-terminally processed.
DOMAIN       11     90       RRM 1.
DOMAIN      111    188       RRM 2.
REPEAT      234    249       1-1.
DOMAIN      289    364       RRM 3.
REPEAT      354    372       2-1.
REPEAT      374    392       2-2.
REPEAT      418    433       1-2.
REGION      234    433       2 X 16 AA Gly-rich approximate repeats.
REGION      354    392       2 X 19 AA perfect repeats.
MOD_RES       1      1       N-acetylmethionine; in Heterogeneous
                             nuclear ribonucleoprotein H; alternate
                             (By similarity).
MOD_RES       2      2       N-acetylmethionine; in Heterogeneous
                             nuclear ribonucleoprotein H, N-terminally
                             processed (By similarity).
MOD_RES      23     23       Phosphoserine (By similarity).
MOD_RES      63     63       Phosphoserine (By similarity).
MOD_RES     100    100       Phosphothreonine (By similarity).
MOD_RES     104    104       Phosphoserine.
MOD_RES     107    107       Phosphothreonine (By similarity).
MOD_RES     217    217       Asymmetric dimethylarginine (By
MOD_RES     233    233       Dimethylated arginine; alternate (By
MOD_RES     233    233       Omega-N-methylarginine; alternate (By
MOD_RES     246    246       Phosphotyrosine (By similarity).
MOD_RES     306    306       Phosphotyrosine (By similarity).
MOD_RES     310    310       Phosphoserine (By similarity).
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Nucleotide Sequence
Length: 2181 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 449 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
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