Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
39221 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
Solute carrier family 25 member 39 
Protein Synonyms/Alias
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

2. Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unknown components, we utilized a large-scale computational screen to identify mitochondrial proteins whose transcripts consistently coexpress with the core machinery of heme biosynthesis. We identified SLC25A39, SLC22A4, and TMEM14C, which are putative mitochondrial transporters, as well as C1orf69 and ISCA1, which are iron-sulfur cluster proteins. Targeted knockdowns of all five genes in zebrafish resulted in profound anemia without impacting erythroid lineage specification. Moreover, silencing of Slc25a39 in murine erythroleukemia cells impaired iron incorporation into protoporphyrin IX, and vertebrate Slc25a39 complemented an iron homeostasis defect in the orthologous yeast mtm1Delta deletion mutant. Our results advance the molecular understanding of heme biosynthesis and offer promising candidate genes for inherited anemias. PMID: [19656490] 

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Required for normal heme biosynthesis (By similarity). 
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Subcellular Location
Mitochondrion inner membrane; Multi-passmembrane protein (By similarity). 
Tissue Specificity
Abundant expression in bone marrow, spleen,testis and kidney. 
Gene Ontology
GO IDGO termEvidence
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0005743 C:mitochondrial inner membrane IEA:UniProtKB-SubCell.
GO:0005739 C:mitochondrion IDA:MGI.
GO:0006783 P:heme biosynthetic process IEA:UniProtKB-KW.
GO:0006810 P:transport IEA:UniProtKB-KW.
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IPR018108;    Mitochondrial_sb/sol_carrier.
IPR023395;    Mt_carrier_dom.
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PF00153;    Mito_carr;    4.
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PS50920;    SOLCAR;    3.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    359       Solute carrier family 25 member 39.
TRANSMEM     15     35       Helical; Name=1; (Potential).
TRANSMEM    122    142       Helical; Name=2; (Potential).
TRANSMEM    165    185       Helical; Name=3; (Potential).
TRANSMEM    215    235       Helical; Name=4; (Potential).
TRANSMEM    256    276       Helical; Name=5; (Potential).
TRANSMEM    318    338       Helical; Name=6; (Potential).
REPEAT        9    151       Solcar 1.
REPEAT      159    243       Solcar 2.
REPEAT      253    347       Solcar 3.
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Nucleotide Sequence
Length: 1450 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 359 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
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Other Protein-Protein interaction resources
String database  
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