Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
20156 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
Diphosphoinositol polyphosphate phosphohydrolase 2 
Protein Synonyms/Alias
DIPP-2EC= Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2;EC=3.6.1.- Nucleoside diphosphate-linked moiety X motif 4;Nudix motif 4 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Cleaves a beta-phosphate from the diphosphate groups inPP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and[PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggestingthat it may play a role in signal transduction. Also able tocatalyze the hydrolysis of dinucleoside oligophosphate Ap6A, butnot Ap5A. The major reaction products are ADP and p4a from Ap6A.Also able to hydrolyze 5-phosphoribose 1-diphosphate (Bysimilarity). 
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Subcellular Location
Cytoplasm (By similarity). 
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell.
GO:0008486 F:diphosphoinositol-polyphosphate diphosphatase activity ISS:UniProtKB.
GO:0052840 F:inositol diphosphate tetrakisphosphate diphosphatase activity IEA:EC.
GO:0052846 F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity IEA:EC.
GO:0052847 F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity IEA:EC.
GO:0052843 F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA:EC.
GO:0052848 F:inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity IEA:EC.
GO:0052844 F:inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity IEA:EC.
GO:0052845 F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IEA:EC.
GO:0046872 F:metal ion binding IEA:UniProtKB-KW.
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IPR020084;    NUDIX_hydrolase_CS.
IPR000086;    NUDIX_hydrolase_dom.
IPR015797;    NUDIX_hydrolase_dom-like.
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PF00293;    NUDIX;    1.
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PS51462;    NUDIX;    1.
PS00893;    NUDIX_BOX;    1.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    179       Diphosphoinositol polyphosphate
                             phosphohydrolase 2.
DOMAIN       17    143       Nudix hydrolase.
REGION       17     19       Substrate binding (By similarity).
REGION       88     90       Substrate binding (By similarity).
MOTIF        50     71       Nudix box.
ACT_SITE     68     68       Proton acceptor (By similarity).
METAL        49     49       Magnesium 1; via carbonyl oxygen (By
METAL        65     65       Magnesium 2 (By similarity).
METAL        65     65       Magnesium 3 (By similarity).
METAL        69     69       Magnesium 1 (By similarity).
BINDING       9      9       Substrate (By similarity).
BINDING      40     40       Substrate (By similarity).
CONFLICT     69     69       E -> Q (in Ref. 1; BAC33229).
CONFLICT    168    168       A -> C (in Ref. 1; BAB30582).
STRAND       17     27
STRAND       32     37
STRAND       44     46
STRAND       49     51
HELIX        58     69
STRAND       72     85
TURN         86     89
STRAND       90    102
HELIX       109    112
STRAND      116    120
HELIX       121    129
HELIX       133    139
TURN        140    142
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Nucleotide Sequence
Length: 1040 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 179 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
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