Tag Content
SG ID
SG00004595 
UniProt Accession
Theoretical PI
8.75  
Molecular Weight
76069 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Mum1 
Gene Synonyms/Alias
 
Protein Name
PWWP domain-containing protein MUM1 
Protein Synonyms/Alias
Mutated melanoma-associated antigen 1;MUM-1 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:10;79689179-79706648;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.699118842 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
Involved in the DNA damage response pathway bycontributing to the maintenance of chromatin architecture.Recruited to the vicinity of DNA breaks by TP53BP1 and plays anaccessory role to facilitate damage-induced chromatin changes andpromoting chromatin relaxation. Required for efficient DNA repairand cell survival following DNA damage (By similarity). 
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Subcellular Location
Nucleus (By similarity). Note=Recuited toDNA damage sites via its interaction with the BRCT domain ofTP53BP1 (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus ISS:UniProtKB.
GO:0031491 F:nucleosome binding ISS:UniProtKB.
GO:0006325 P:chromatin organization ISS:UniProtKB.
GO:0006281 P:DNA repair ISS:UniProtKB.
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Interpro
Pfam
SMART
PROSITE
PS50812;    PWWP;    FALSE_NEG.
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PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    682       PWWP domain-containing protein MUM1.
                             /FTId=PRO_0000295047.
DOMAIN      383    444       PWWP.
CONFLICT     59     59       L -> M (in Ref. 1; BAC37397).
CONFLICT    374    374       L -> Q (in Ref. 3; BAA82658).
CONFLICT    400    406       VVKSVRR -> PTRPVRP (in Ref. 2; AAH69883).
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Nucleotide Sequence
Length: 2180 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 682 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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