SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00004902 
UniProt Accession
Theoretical PI
9.73  
Molecular Weight
27964 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Bcap29 
Gene Synonyms/Alias
Bap29 
Protein Name
B-cell receptor-associated protein 29 
Protein Synonyms/Alias
BCR-associated protein 29Bap29 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:12;32280219-32319462;-1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.823168278 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. The IgM and IgD classes of antigen receptor can perform different functions on B cells. However, so far no class-specific components communicating with the cytoplasm have been found in the two antigen receptors. We have employed a new biotinylation protocol to search for intracellular membrane Ig-associated proteins. Here we describe two proteins of 29 and 31 kDa that are associated with membrane IgD and to some extent with membrane IgM. The membrane IgM molecule is associated specifically with three proteins of 32, 37 and 41 kDa. The purification and sequencing of the two mIgD-associated proteins revealed that they are novel proteins which are related to each other. These proteins may be the missing link between the antigen receptor and the cytoskeleton and may contribute to functional differences between membrane IgM and membrane IgD. PMID: [8070407] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
May play a role in anterograde transport of membraneproteins from the endoplasmic reticulum to the Golgi. May beinvolved in CASP8-mediated apoptosis (By similarity). 
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Subcellular Location
Endoplasmic reticulum membrane; Multi-passmembrane protein. 
Tissue Specificity
Highly expressed in brain and testis; detectedat lower levels in thymus, spleen, liver, lung and bone marrow. 
Gene Ontology
GO IDGO termEvidence
GO:0005789 C:endoplasmic reticulum membrane IEA:UniProtKB-SubCell.
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0006915 P:apoptotic process IEA:UniProtKB-KW.
GO:0006886 P:intracellular protein transport IEA:InterPro.
GO:0016192 P:vesicle-mediated transport IEA:UniProtKB-KW.
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Interpro
IPR008417;    Bap31.
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Pfam
PF05529;    Bap31;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    240       B-cell receptor-associated protein 29.
                             /FTId=PRO_0000142889.
TOPO_DOM      1      6       Lumenal (Potential).
TRANSMEM      7     27       Helical; (Potential).
TOPO_DOM     28     43       Cytoplasmic (Potential).
TRANSMEM     44     64       Helical; (Potential).
TOPO_DOM     65    103       Lumenal (Potential).
TRANSMEM    104    124       Helical; (Potential).
TOPO_DOM    125    240       Cytoplasmic (Potential).
MOTIF       237    240       Di-lysine motif.
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Nucleotide Sequence
Length: 1729 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 240 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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