Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
19519 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
Protein Synonyms/Alias
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. Among the numerous centrin isoforms identified by two-dimensional gel electrophoresis in human cells, an acidic and slow-migrating isoform is particularly enriched in a centrosome fraction. We report here that this isoform specifically reacts with antibodies raised against Saccharomyces cerevisiae Cdc31p and is present, as other centrin isoforms, in the distal lumen of centrioles. It is encoded by a new centrin gene, which we propose to name HsCEN3 (Homo sapiens centrin gene 3). This gene is more closely related to the yeast CDC31 gene, and shares less identity with algae centrin than HsCEN1 and HsCEN2. A murine CDC31-related gene was also found that shows 98% identity and 100% similarity with HsCEN3, demonstrating a higher interspecies conservation than the murine centrin gene MmCEN1 (Mus musculus centrin gene 1) with either HsCEN1, or HsCEN2. Finally, immunological data suggest that a CDC31-related gene could exist in amphibians and echinoderms as well. All together, our data suggest the existence of two divergent protein subfamilies in the current centrin family, which might be involved in distinct centrosome-associated functions. The possible implication of this new mammalian centrin gene in centrosome duplication is discussed. PMID: [9256449] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Plays a fundamental role in microtubule-organizingcenter structure and function. 
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Subcellular Location
Cytoplasm, cytoskeleton, centrosome.Note=Centrosome of interphase and mitotic cells. 
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0005814 C:centriole IDA:MGI.
GO:0045111 C:intermediate filament cytoskeleton IEA:Compara.
GO:0005932 C:microtubule basal body IDA:MGI.
GO:0032391 C:photoreceptor connecting cilium IDA:MGI.
GO:0005509 F:calcium ion binding IEA:InterPro.
GO:0051301 P:cell division IEA:UniProtKB-KW.
GO:0007067 P:mitosis IEA:UniProtKB-KW.
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IPR011992;    EF-hand-like_dom.
IPR018247;    EF_Hand_1_Ca_BS.
IPR018249;    EF_HAND_2.
IPR002048;    EF_hand_Ca-bd.
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SM00054;    EFh;    4.
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PS00018;    EF_HAND_1;    2.
PS50222;    EF_HAND_2;    4.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    167       Centrin-3.
DOMAIN       25     60       EF-hand 1.
DOMAIN       61     96       EF-hand 2.
DOMAIN       98    133       EF-hand 3.
DOMAIN      134    167       EF-hand 4.
CA_BIND      38     49       1 (Potential).
CA_BIND     147    158       2 (Probable).
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Nucleotide Sequence
Length: 504 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 167 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data