Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
18186 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
Signal peptidase complex subunit 1 
Protein Synonyms/Alias
EC=3.4.-.- Microsomal signal peptidase 12 kDa subunit;SPase 12 kDa subunit 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

2. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

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Component of the microsomal signal peptidase complexwhich removes signal peptides from nascent proteins as they aretranslocated into the lumen of the endoplasmic reticulum (Bysimilarity). 
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Subcellular Location
Microsome membrane; Multi-pass membraneprotein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). 
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0030176 C:integral to endoplasmic reticulum membrane ISS:UniProtKB.
GO:0005787 C:signal peptidase complex IEA:InterPro.
GO:0008233 F:peptidase activity IEA:UniProtKB-KW.
GO:0043022 F:ribosome binding IDA:MGI.
GO:0006508 P:proteolysis IEA:UniProtKB-KW.
GO:0006465 P:signal peptide processing IEA:InterPro.
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IPR009542;    SPC12.
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PF06645;    SPC12;    1.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    161       Signal peptidase complex subunit 1.
TOPO_DOM      1     85       Cytoplasmic (Potential).
TRANSMEM     86    106       Helical; (Potential).
TOPO_DOM    107    107       Extracellular (Potential).
TRANSMEM    108    128       Helical; (Potential).
TOPO_DOM    129    161       Cytoplasmic (Potential).
CONFLICT     40     40       T -> A (in Ref. 1; AAH49895).
CONFLICT     86     86       I -> V (in Ref. 2; BAB24969).
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Nucleotide Sequence
Length: 932 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 161 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data