Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
32297 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Pab2, Pabp2 
Protein Name
Polyadenylate-binding protein 2 
Protein Synonyms/Alias
PABP-2Poly(A)-binding protein 2 Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II;PABII Polyadenylate-binding nuclear protein 1; 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. The genomic structure and expression of the murine poly(A) binding protein II (mPABII) gene were analyzed by using genomic DNA and cDNA clones. The expression level of the mPABII gene varied among tissues. Besides two transcripts detected in all tissues, an additional transcript was detected in testis. The mPAB gene has pseudogenes or related genes in its genome. PMID: [9434149] 

2. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

3. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Involved in the 3'-end formation of mRNA precursors(pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to theupstream cleavage product. Stimulates poly(A) polymerase (PAPOLA)conferring processivity on the poly(A) tail elongation reactionand controls also the poly(A) tail length. Increases the affinityof poly(A) polymerase for RNA. Is also present at various stagesof mRNA metabolism including nucleocytoplasmic trafficking andnonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP tosynergistically activate E-box-mediated transcription throughMYOD1 and may regulate the expression of muscle-specific genes.Binds to poly(A) and to poly(G) with high affinity. May protectthe poly(A) tail from degradation (By similarity). 
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Subcellular Location
Cytoplasm (By similarity). Nucleus (Bysimilarity). Note=Localized in cytoplasmic mRNP granulescontaining untranslated mRNAs. Shuttles between the nucleus andthe cytoplasm but predominantly found in the nucleus. Its nuclearimport may involve the nucleocytoplasmic transport receptortransportin and a RAN-GTP-sensitive import mechanism. It isexported to the cytoplasm by a carrier-mediated pathway that isindependent of mRNA traffic. Nucleus; nuclear speckle (Bysimilarity). Colocalizes with SKIP and poly(A) RNA in nuclearspeckles (By similarity). 
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell.
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0030529 C:ribonucleoprotein complex ISS:UniProtKB.
GO:0000166 F:nucleotide binding IEA:InterPro.
GO:0008143 F:poly(A) RNA binding TAS:MGI.
GO:0006378 P:mRNA polyadenylation TAS:MGI.
GO:0016973 P:poly(A)+ mRNA export from nucleus IEA:Compara.
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IPR012677;    Nucleotide-bd_a/b_plait.
IPR000504;    RRM_dom.
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PF00076;    RRM_1;    1.
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SM00360;    RRM;    1.
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PS50102;    RRM;    1.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
INIT_MET      1      1       Removed (By similarity).
CHAIN         2    302       Polyadenylate-binding protein 2.
DOMAIN      168    245       RRM.
REGION        2    141       Interacts with SKIP (By similarity).
REGION      115    143       Stimulates PAPOLA (By similarity).
REGION      255    302       Strong poly(A) affinity and self-
                             association (By similarity).
REGION      282    302       Interacts with PAPOLA (By similarity).
COILED      111    147       Potential.
COMPBIAS      2     14       Ala-rich.
MOD_RES       2      2       N-acetylalanine (By similarity).
MOD_RES      19     19       Phosphoserine (By similarity).
MOD_RES      52     52       Phosphoserine (By similarity).
MOD_RES      91     91       Phosphoserine (By similarity).
MOD_RES     146    146       Phosphoserine (By similarity).
MOD_RES     234    234       Asymmetric dimethylarginine (By
MOD_RES     255    255       Asymmetric dimethylarginine (By
MOD_RES     259    259       Asymmetric dimethylarginine (By
MOD_RES     263    263       Asymmetric dimethylarginine (By
MOD_RES     265    265       Asymmetric dimethylarginine (By
MOD_RES     273    273       Asymmetric dimethylarginine (By
MOD_RES     275    275       Asymmetric dimethylarginine (By
MOD_RES     283    283       Asymmetric dimethylarginine (By
MOD_RES     285    285       Asymmetric dimethylarginine (By
MOD_RES     287    287       Asymmetric dimethylarginine (By
MOD_RES     290    290       Asymmetric dimethylarginine (By
MOD_RES     292    292       Asymmetric dimethylarginine (By
MOD_RES     294    294       Asymmetric dimethylarginine (By
VAR_SEQ     291    292       GR -> SG (in isoform 2).
VAR_SEQ     293    302       Missing (in isoform 2).
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Nucleotide Sequence
Length: 5164 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 302 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
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