SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00006265 
UniProt Accession
Theoretical PI
5.79  
Molecular Weight
26809 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Adipoq 
Gene Synonyms/Alias
Acdc, Acrp30, Apm1 
Protein Name
Adiponectin 
Protein Synonyms/Alias
30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein;ACRP30 Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ;Flags: Precursor 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:16;23146609-23158101;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.16570379 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the availability of a finished, high-quality genome assembly. The finished clone-based assembly of the mouse strain C57BL/6J reported here has over 175,000 fewer gaps and over 139 Mb more of novel sequence, compared with the earlier MGSCv3 draft genome assembly. In a comprehensive analysis of this revised genome sequence, we are now able to define 20,210 protein-coding genes, over a thousand more than predicted in the human genome (19,042 genes). In addition, we identified 439 long, non-protein-coding RNAs with evidence for transcribed orthologs in human. We analyzed the complex and repetitive landscape of 267 Mb of sequence that was missing or misassembled in the previously published assembly, and we provide insights into the reasons for its resistance to sequencing and assembly by whole-genome shotgun approaches. Duplicated regions within newly assembled sequence tend to be of more recent ancestry than duplicates in the published draft, correcting our initial understanding of recent evolution on the mouse lineage. These duplicates appear to be largely composed of sequence regions containing transposable elements and duplicated protein-coding genes; of these, some may be fixed in the mouse population, but at least 40% of segmentally duplicated sequences are copy number variable even among laboratory mouse strains. Mouse lineage-specific regions contain 3,767 genes drawn mainly from rapidly-changing gene families associated with reproductive functions. The finished mouse genome assembly, therefore, greatly improves our understanding of rodent-specific biology and allows the delineation of ancestral biological functions that are shared with human from derived functions that are not. PMID: [19468303] 

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Function
Important adipokine involved in the control of fatmetabolism and insulin sensitivity, with direct anti-diabetic,anti-atherogenic and anti-inflammatory activities. Stimulates AMPKphosphorylation and activation in the liver and the skeletalmuscle, enhancing glucose utilization and fatty-acid combustion.Antagonizes TNF-alpha by negatively regulating its expression invarious tissues such as liver and macrophages, and also bycounteracting its effects. Inhibits endothelial NF-kappa-Bsignaling through a cAMP-dependent pathway. May play a role incell growth, angiogenesis and tissue remodeling by binding andsequestering various growth factors with distinct bindingaffinities, depending on the type of complex, LMW, MMW or HMW. 
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Subcellular Location
Secreted. 
Tissue Specificity
Synthesized exclusively by adipocytes andsecreted into plasma. 
Gene Ontology
GO IDGO termEvidence
GO:0071944 C:cell periphery ISS:UniProtKB.
GO:0005581 C:collagen IEA:UniProtKB-KW.
GO:0005783 C:endoplasmic reticulum IDA:MGI.
GO:0005615 C:extracellular space IDA:MGI.
GO:0048471 C:perinuclear region of cytoplasm ISS:UniProtKB.
GO:0043499 F:eukaryotic cell surface binding ISS:UniProtKB.
GO:0050873 P:brown fat cell differentiation IDA:MGI.
GO:0035690 P:cellular response to drug IDA:UniProtKB.
GO:0032869 P:cellular response to insulin stimulus IGI:MGI.
GO:0070994 P:detection of oxidative stress IMP:UniProtKB.
GO:0006635 P:fatty acid beta-oxidation IMP:MGI.
GO:0042593 P:glucose homeostasis IDA:MGI.
GO:0006006 P:glucose metabolic process IDA:MGI.
GO:0034383 P:low-density lipoprotein particle clearance ISS:UniProtKB.
GO:0045776 P:negative regulation of blood pressure ISS:UniProtKB.
GO:2000279 P:negative regulation of DNA biosynthetic process ISS:UniProtKB.
GO:0070373 P:negative regulation of ERK1 and ERK2 cascade ISS:UniProtKB.
GO:2000461 P:negative regulation of eukaryotic cell surface binding ISS:UniProtKB.
GO:0045599 P:negative regulation of fat cell differentiation IDA:BHF-UCL.
GO:0045721 P:negative regulation of gluconeogenesis IDA:MGI.
GO:0030853 P:negative regulation of granulocyte differentiation ISS:UniProtKB.
GO:0034115 P:negative regulation of heterotypic cell-cell adhesion ISS:UniProtKB.
GO:0043124 P:negative regulation of I-kappaB kinase/NF-kappaB cascade ISS:UniProtKB.
GO:0050728 P:negative regulation of inflammatory response IDA:UniProtKB.
GO:0090317 P:negative regulation of intracellular protein transport ISS:UniProtKB.
GO:0045715 P:negative regulation of low-density lipoprotein particle receptor biosynthetic process ISS:UniProtKB.
GO:0010745 P:negative regulation of macrophage derived foam cell differentiation ISS:UniProtKB.
GO:0045650 P:negative regulation of macrophage differentiation ISS:UniProtKB.
GO:0043407 P:negative regulation of MAP kinase activity IDA:UniProtKB.
GO:2000590 P:negative regulation of metanephric mesenchymal cell migration IDA:UniProtKB.
GO:0050765 P:negative regulation of phagocytosis ISS:UniProtKB.
GO:2000584 P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IDA:UniProtKB.
GO:0031953 P:negative regulation of protein autophosphorylation ISS:UniProtKB.
GO:0014912 P:negative regulation of smooth muscle cell migration ISS:UniProtKB.
GO:0048662 P:negative regulation of smooth muscle cell proliferation ISS:UniProtKB.
GO:0050805 P:negative regulation of synaptic transmission ISS:UniProtKB.
GO:0045892 P:negative regulation of transcription, DNA-dependent IMP:UniProtKB.
GO:0032720 P:negative regulation of tumor necrosis factor production ISS:UniProtKB.
GO:0010804 P:negative regulation of tumor necrosis factor-mediated signaling pathway ISS:UniProtKB.
GO:2000481 P:positive regulation of cAMP-dependent protein kinase activity IMP:UniProtKB.
GO:0010875 P:positive regulation of cholesterol efflux ISS:UniProtKB.
GO:0045923 P:positive regulation of fatty acid metabolic process IMP:MGI.
GO:0046326 P:positive regulation of glucose import IDA:MGI.
GO:2000467 P:positive regulation of glycogen (starch) synthase activity ISS:UniProtKB.
GO:0043123 P:positive regulation of I-kappaB kinase/NF-kappaB cascade IDA:MGI.
GO:0032757 P:positive regulation of interleukin-8 production ISS:UniProtKB.
GO:2000478 P:positive regulation of metanephric glomerular visceral epithelial cell development IMP:UniProtKB.
GO:0071639 P:positive regulation of monocyte chemotactic protein-1 production ISS:UniProtKB.
GO:0033034 P:positive regulation of myeloid cell apoptotic process ISS:UniProtKB.
GO:0010739 P:positive regulation of protein kinase A signaling cascade ISS:UniProtKB.
GO:2000534 P:positive regulation of renal albumin absorption IMP:UniProtKB.
GO:0070208 P:protein heterotrimerization IPI:MGI.
GO:0051260 P:protein homooligomerization IDA:MGI.
GO:0072659 P:protein localization in plasma membrane ISS:UniProtKB.
GO:0009749 P:response to glucose stimulus IDA:MGI.
GO:0034612 P:response to tumor necrosis factor ISS:UniProtKB.
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Interpro
IPR001073;    C1q.
IPR008160;    Collagen.
IPR008983;    Tumour_necrosis_fac-like.
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Pfam
PF00386;    C1q;    1.
PF01391;    Collagen;    1.
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SMART
SM00110;    C1Q;    1.
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PROSITE
PS50871;    C1Q;    1.
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PRINTS
PR00007;    COMPLEMNTC1Q.;   
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Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
SIGNAL        1     17
CHAIN        18    247       Adiponectin.
                             /FTId=PRO_0000003544.
DOMAIN       45    110       Collagen-like.
DOMAIN      111    247       C1q.
SITE         79     79       Not hydroxylated.
SITE         98     98       Not hydroxylated.
SITE        107    107       Not hydroxylated.
SITE        233    233       Not glycosylated.
MOD_RES      47     47       4-hydroxyproline (By similarity).
MOD_RES      50     50       4-hydroxyproline (By similarity).
MOD_RES      56     56       4-hydroxyproline (By similarity).
MOD_RES      68     68       5-hydroxylysine.
MOD_RES      71     71       5-hydroxylysine.
MOD_RES      80     80       5-hydroxylysine.
MOD_RES      94     94       4-hydroxyproline.
MOD_RES     104    104       5-hydroxylysine.
CARBOHYD     23     23       O-linked (GalNAc...) (Probable).
CARBOHYD     24     24       O-linked (GalNAc...) (Probable).
CARBOHYD     68     68       O-linked (Gal...).
CARBOHYD     71     71       O-linked (Gal...).
CARBOHYD     80     80       O-linked (Gal...).
CARBOHYD    104    104       O-linked (Gal...).
DISULFID     39     39       Interchain (By similarity).
MUTAGEN      39     39       C->A: No change in the interaction with
                             CTRP9.
MUTAGEN      68     68       K->R: Impaired formation of HMW
                             multimers; when associated with R-71; R-
                             80 and R-104.
MUTAGEN      71     71       K->R: Impaired formation of HMW
                             multimers; when associated with R-68; R-
                             80 and R-104.
MUTAGEN      80     80       K->R: Impaired formation of HMW
                             multimers; when associated with R-68; R-
                             71 and R-104.
MUTAGEN     104    104       K->R: Impaired formation of HMW
                             multimers; when associated with R-68; R-
                             71 and R-80.
CONFLICT     50     50       P -> S (in Ref. 2; AAB06706).
CONFLICT     74     74       A -> S (in Ref. 2; AAB06706).
CONFLICT    113    113       V -> M (in Ref. 1; AAA80543 and 3;
                             AAK13417).
CONFLICT    117    117       A -> G (in Ref. 2; AAB06706).
CONFLICT    148    148       G -> N (in Ref. 2; AAB06706).
CONFLICT    243    243       Y -> F (in Ref. 2; AAB06706).
STRAND      117    121
STRAND      130    132
STRAND      137    140
TURN        148    150
STRAND      152    154
STRAND      159    172
STRAND      174    180
STRAND      183    190
STRAND      197    208
STRAND      213    218
STRAND      236    244
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Nucleotide Sequence
Length: 1276 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 247 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
AdipoqDIP 
AdipoqDIP 
Gstk1DIP 
ADIPOR1DIP 
GSTK1DIP 
Other Protein-Protein interaction resources
String database  
View Microarray data
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