SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00006397 
UniProt Accession
Theoretical PI
5.26  
Molecular Weight
61195 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Amhr2 
Gene Synonyms/Alias
 
Protein Name
Anti-Muellerian hormone type-2 receptor 
Protein Synonyms/Alias
EC=2.7.11.30 Anti-Muellerian hormone type II receptor;AMH type II receptor MIS type II receptor;MISRIIMRIIFlags: Precursor 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:15;102275798-102285061;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.650565061 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. We have determined the sequence and structure of the mouse Müllerian-inhibiting substance (MIS) type II receptor gene. Sequence comparisons demonstrate that the mouse, rat, rabbit, and human MIS type II receptors are highly conserved. The mouse MIS type II receptor gene is encoded by 11 exons and spans approximately 9-kb. Only half of the intron/exon boundaries of its kinase domain are conserved in comparison to the kinase domain of the related activin type II receptor. Whereas the activin type II receptor gene contains large introns (> 40-kb), the largest intron of the MIS type II receptor gene is only 4.3-kb. The MIS type II receptor gene (Amhr) is closely linked to Hoxc on mouse chromosome 15. Knowledge of the sequence and genomic structure of Amhr provides important information for the genetic manipulation of the Amhr locus. PMID: [9299437] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threoninekinases. Type II receptors phosphorylate and activate type Ireceptors which autophosphorylate, then bind and activate SMADtranscriptional regulators. Receptor for anti-Muellerian hormone. 
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Subcellular Location
Membrane; Single-pass type I membraneprotein (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005887 C:integral to plasma membrane ISO:MGI.
GO:0005524 F:ATP binding IEA:UniProtKB-KW.
GO:0042562 F:hormone binding ISS:UniProtKB.
GO:0046872 F:metal ion binding IEA:UniProtKB-KW.
GO:0005026 F:transforming growth factor beta receptor activity, type II IEA:Compara.
GO:0005024 F:transforming growth factor beta-activated receptor activity TAS:MGI.
GO:0007548 P:sex differentiation IMP:MGI.
GO:0007179 P:transforming growth factor beta receptor signaling pathway TAS:MGI.
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Interpro
IPR000472;    Activin_rcpt.
IPR015771;    Anti-muellerian_hrmn_rcpt_II.
IPR011009;    Kinase-like_dom.
IPR000719;    Prot_kinase_cat_dom.
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Pfam
PF01064;    Activin_recp;    1.
PF00069;    Pkinase;    1.
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SMART
PROSITE
PS00107;    PROTEIN_KINASE_ATP;    FALSE_NEG.
PS50011;    PROTEIN_KINASE_DOM;    1.
PS00108;    PROTEIN_KINASE_ST;    FALSE_NEG.
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PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
SIGNAL        1     15       Potential.
CHAIN        16    568       Anti-Muellerian hormone type-2 receptor.
                             /FTId=PRO_0000260265.
TOPO_DOM     16    147       Extracellular (Potential).
TRANSMEM    148    168       Helical; (Potential).
TOPO_DOM    169    568       Cytoplasmic (Potential).
DOMAIN      199    504       Protein kinase.
NP_BIND     205    213       ATP (By similarity).
ACT_SITE    329    329       Proton acceptor (By similarity).
BINDING     226    226       ATP (By similarity).
CARBOHYD     66     66       N-linked (GlcNAc...) (Potential).
CARBOHYD    119    119       N-linked (GlcNAc...) (Potential).
CONFLICT    240    240       R -> G (in Ref. 1; AAM28608).
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Nucleotide Sequence
Length: 1885 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 568 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
YwhazIntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
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