Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
64802 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
La-related protein 7 
Protein Synonyms/Alias
La ribonucleoprotein domain family member 7; 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the availability of a finished, high-quality genome assembly. The finished clone-based assembly of the mouse strain C57BL/6J reported here has over 175,000 fewer gaps and over 139 Mb more of novel sequence, compared with the earlier MGSCv3 draft genome assembly. In a comprehensive analysis of this revised genome sequence, we are now able to define 20,210 protein-coding genes, over a thousand more than predicted in the human genome (19,042 genes). In addition, we identified 439 long, non-protein-coding RNAs with evidence for transcribed orthologs in human. We analyzed the complex and repetitive landscape of 267 Mb of sequence that was missing or misassembled in the previously published assembly, and we provide insights into the reasons for its resistance to sequencing and assembly by whole-genome shotgun approaches. Duplicated regions within newly assembled sequence tend to be of more recent ancestry than duplicates in the published draft, correcting our initial understanding of recent evolution on the mouse lineage. These duplicates appear to be largely composed of sequence regions containing transposable elements and duplicated protein-coding genes; of these, some may be fixed in the mouse population, but at least 40% of segmentally duplicated sequences are copy number variable even among laboratory mouse strains. Mouse lineage-specific regions contain 3,767 genes drawn mainly from rapidly-changing gene families associated with reproductive functions. The finished mouse genome assembly, therefore, greatly improves our understanding of rodent-specific biology and allows the delineation of ancestral biological functions that are shared with human from derived functions that are not. PMID: [19468303] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

3. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

4. Protein phosphorylation is a complex network of signaling and regulatory events that affects virtually every cellular process. Our understanding of the nature of this network as a whole remains limited, largely because of an array of technical challenges in the isolation and high-throughput sequencing of phosphorylated species. In the present work, we demonstrate that a combination of tandem phosphopeptide enrichment methods, high performance MS, and optimized database search/data filtering strategies is a powerful tool for surveying the phosphoproteome. Using our integrated analytical platform, we report the identification of 5,635 nonredundant phosphorylation sites from 2,328 proteins from mouse liver. From this list of sites, we extracted both novel and known motifs for specific Ser/Thr kinases including a "dipolar" motif. We also found that C-terminal phosphorylation was more frequent than at any other location and that the distribution of potential kinases for these sites was unique. Finally, we identified double phosphorylation motifs that may be involved in ordered phosphorylation. PMID: [17242355] 

5. Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion of this pathway are known, but little is known about the physiological scope of the DNA damage response (DDR). We performed a large-scale proteomic analysis of proteins phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR and identified more than 900 regulated phosphorylation sites encompassing over 700 proteins. Functional analysis of a subset of this data set indicated that this list is highly enriched for proteins involved in the DDR. This set of proteins is highly interconnected, and we identified a large number of protein modules and networks not previously linked to the DDR. This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals. PMID: [17525332] 

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Negative transcriptional regulator of polymerase IIgenes, acting by means of the 7SK RNP system. Within the 7SK RNPcomplex, the positive transcription elongation factor b (P-TEFb)is sequestered in an inactive form, preventing RNA polymerase IIphosphorylation and subsequent transcriptional elongation (Bysimilarity). 
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Subcellular Location
Nucleus, nucleoplasm (By similarity). 
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0005654 C:nucleoplasm IEA:UniProtKB-SubCell.
GO:0030529 C:ribonucleoprotein complex IEA:InterPro.
GO:0000166 F:nucleotide binding IEA:InterPro.
GO:0003723 F:RNA binding IEA:UniProtKB-KW.
GO:0006396 P:RNA processing IEA:InterPro.
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IPR002344;    Lupus_La.
IPR006630;    Lupus_La_RNA-bd.
IPR012677;    Nucleotide-bd_a/b_plait.
IPR014886;    RRM_3.
IPR000504;    RRM_dom.
IPR011991;    WHTH_trsnscrt_rep_DNA-bd.
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PF05383;    La;    1.
PF00076;    RRM_1;    1.
PF08777;    RRM_3;    1.
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SM00715;    LA;    1.
SM00360;    RRM;    1.
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PS50961;    HTH_LA;    1.
PS50102;    RRM;    1.
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PR00302;    LUPUSLA.;   
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    570       La-related protein 7.
DOMAIN       22    116       HTH La-type RNA-binding.
DOMAIN      119    197       RRM.
COMPBIAS    196    364       Lys-rich.
MOD_RES     253    253       Phosphoserine (By similarity).
MOD_RES     256    256       Phosphoserine (By similarity).
MOD_RES     260    260       Phosphothreonine.
MOD_RES     334    334       Phosphoserine (By similarity).
MOD_RES     335    335       Phosphothreonine (By similarity).
MOD_RES     428    428       Phosphothreonine.
VAR_SEQ     179    185       FLNNPPE -> VRTSVGP (in isoform 2).
VAR_SEQ     186    570       Missing (in isoform 2).
CONFLICT     13     13       T -> TE (in Ref. 2; BC020127).
CONFLICT    202    202       P -> L (in Ref. 2; AAH23165).
CONFLICT    214    214       K -> R (in Ref. 3; BAB28459).
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Nucleotide Sequence
Length: 157006 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 570 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data