Tag Content
SG ID
SG00011008 
UniProt Accession
Theoretical PI
9.64  
Molecular Weight
33579 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Spata4 
Gene Synonyms/Alias
Srg2, Tsarg2 
Protein Name
Spermatogenesis-associated protein 4 
Protein Synonyms/Alias
Spermatogenesis-related gene 2 protein; Testis and spermatogenesis cell-related protein 2; Testis spermatocyte apoptosis-related gene 2 protein; 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:8;55686134-55695451;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.999923603 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. A novel mouse gene full-length cDNA sequence-SRG2 were identified (GenBank accession number AF395083), which was significantly changed in cryptorchidism, from a mouse testis cDNA library using a cDNA fragment (GenBank accession number BE644542) as an electronic probe. SRG2 was 1058 bp in length. The putative protein encoded by this gene was 295 amino acids with a theoretical molecular weight of 33 579 and isoelectric point of 9.64. The sequence shared no significant homology with any known protein in databases except TSARG2, with which its homology was 78%. RT-PCR showed that SRG2 was expressed significantly in testis. PMID: [12417927] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
 
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Subcellular Location
 
Tissue Specificity
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Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IDA:MGI.
GO:0006915 P:apoptotic process ISS:UniProtKB.
GO:0007283 P:spermatogenesis ISS:UniProtKB.
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Interpro
IPR010441;    DUF1042.
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Pfam
PF06294;    DUF1042;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    295       Spermatogenesis-associated protein 4.
                             /FTId=PRO_0000072102.
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Nucleotide Sequence
Length: 1057 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 295 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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