SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00011129 
UniProt Accession
Theoretical PI
6.41  
Molecular Weight
38752 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Hp 
Gene Synonyms/Alias
 
Protein Name
Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain 
Protein Synonyms/Alias
Zonulin;Contains:Contains:Flags: Precursor 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:8;112099030-112103072;-1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.175165359 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. A procedure to map N-glycosylation sites is presented here. It can be applied to purified proteins as well as to highly complex mixtures. The method exploits deglycosylation by PNGase F in a diagonal, reverse-phase chromatographic setup. When applied to 10 microL of mouse serum, affinity-depleted for its three most abundant components, 117 known or predicted sites were mapped in addition to 10 novel sites. Several sites were detected on soluble membrane or receptor components. Our method furthermore senses the nature of glycan structures and can detect differential glycosylation on a given site. These properties--high sensitivity and dependence on glycan imprinting--can be exploited for glycan-biomarker analysis. PMID: [16944957] 

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Function
Uncleaved haptoglogin, also known as zonulin, plays arole in intestinal permeability, allowing intercellular tightjunction disassembly, and controlling the equilibrium betweentolerance and immunity to non-self antigens (By similarity). 
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Subcellular Location
Secreted (By similarity). 
Tissue Specificity
Expressed by the liver and secreted in plasma. 
Gene Ontology
GO IDGO termEvidence
GO:0005576 C:extracellular region IEA:UniProtKB-SubCell.
GO:0003824 F:catalytic activity IEA:InterPro.
GO:0008152 P:metabolic process IEA:GOC.
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Interpro
IPR016060;    Complement_control_module.
IPR008292;    Haptoglobin.
IPR009003;    Pept_cys/ser_Trypsin-like.
IPR001254;    Peptidase_S1_S6.
IPR001314;    Peptidase_S1A.
IPR000436;    Sushi_SCR_CCP.
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Pfam
PF00089;    Trypsin;    1.
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SMART
SM00032;    CCP;    1.
SM00020;    Tryp_SPc;    1.
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PROSITE
PS50923;    SUSHI;    1.
PS50240;    TRYPSIN_DOM;    1.
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PRINTS
PR00722;    CHYMOTRYPSIN.;   
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Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
SIGNAL        1     18       Potential.
CHAIN        19    347       Haptoglobin.
                             /FTId=PRO_0000028462.
CHAIN        19    101       Haptoglobin alpha chain.
                             /FTId=PRO_0000028463.
CHAIN       103    347       Haptoglobin beta chain.
                             /FTId=PRO_0000028464.
DOMAIN       31     88       Sushi.
DOMAIN      103    345       Peptidase S1.
CARBOHYD    148    148       N-linked (GlcNAc...).
CARBOHYD    182    182       N-linked (GlcNAc...).
CARBOHYD    256    256       N-linked (GlcNAc...).
CARBOHYD    264    264       N-linked (GlcNAc...) (Potential).
DISULFID     33     33       Interchain (By similarity).
DISULFID     52     86       By similarity.
DISULFID     90    207       Interchain (between alpha and beta
                             chains) (By similarity).
DISULFID    250    281       By similarity.
DISULFID    292    322       By similarity.
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Nucleotide Sequence
Length: 1267 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 347 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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