Tag Content
SG ID
SG00012018 
UniProt Accession
Theoretical PI
6.21  
Molecular Weight
12473 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gtf2a2 
Gene Synonyms/Alias
 
Protein Name
Transcription initiation factor IIA subunit 2 
Protein Synonyms/Alias
General transcription factor IIA subunit 2; Transcription initiation factor IIA gamma chain;TFIIA-gamma 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:9;69860357-69870673;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.730053003 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
TFIIA is a component of the transcription machinery ofRNA polymerase II and plays an important role in transcriptionalactivation. TFIIA in a complex with TBP mediates transcriptionalactivity (By similarity). 
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Subcellular Location
Nucleus (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005672 C:transcription factor TFIIA complex IEA:Compara.
GO:0003713 F:transcription coactivator activity IEA:Compara.
GO:0051091 P:positive regulation of sequence-specific DNA binding transcription factor activity IEA:Compara.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter IEA:Compara.
GO:0051123 P:RNA polymerase II transcriptional preinitiation complex assembly IEA:Compara.
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Interpro
IPR009083;    TFIIA_a-hlx.
IPR009088;    TFIIA_b-brl.
IPR003194;    TFIIA_gsu.
IPR015871;    TFIIA_gsu_C.
IPR015872;    TFIIA_gsu_N.
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Pfam
PF02751;    TFIIA_gamma_C;    1.
PF02268;    TFIIA_gamma_N;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    109       Transcription initiation factor IIA
                             subunit 2.
                             /FTId=PRO_0000194043.
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Nucleotide Sequence
Length: 1124 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 109 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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