SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00012127 
UniProt Accession
Theoretical PI
8.35  
Molecular Weight
54753 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Fgb 
Gene Synonyms/Alias
 
Protein Name
Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain 
Protein Synonyms/Alias
Contains:Contains:Flags: Precursor 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:3;82846169-82853725;-1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.106503588 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
Fibrinogen has a double function: yielding monomers thatpolymerize into fibrin and acting as a cofactor in plateletaggregation (By similarity). 
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Subcellular Location
Secreted. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005938 C:cell cortex IDA:MGI.
GO:0009897 C:external side of plasma membrane IEA:Compara.
GO:0005577 C:fibrinogen complex IEA:InterPro.
GO:0031091 C:platelet alpha granule IEA:Compara.
GO:0043499 F:eukaryotic cell surface binding IEA:Compara.
GO:0030168 P:platelet activation IEA:InterPro.
GO:0051258 P:protein polymerization IEA:InterPro.
GO:0051592 P:response to calcium ion IEA:Compara.
GO:0007165 P:signal transduction IEA:InterPro.
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Interpro
IPR002181;    Fibrinogen_a/b/g_C.
IPR014716;    Fibrinogen_a/b/g_C_1.
IPR014715;    Fibrinogen_a/b/g_C_2.
IPR012290;    Fibrinogen_a/b/g_coil_dom.
IPR020837;    Fibrinogen_CS.
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Pfam
PF08702;    Fib_alpha;    1.
PF00147;    Fibrinogen_C;    1.
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SMART
SM00186;    FBG;    1.
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PROSITE
PS00514;    FIBRINOGEN_C_1;    1.
PS51406;    FIBRINOGEN_C_2;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
SIGNAL        1     19       By similarity.
PEPTIDE      20     34       Fibrinopeptide B (By similarity).
                             /FTId=PRO_0000009078.
CHAIN        35    481       Fibrinogen beta chain.
                             /FTId=PRO_0000009077.
DOMAIN      222    478       Fibrinogen C-terminal.
REGION       35     37       Beta-chain polymerization, binding distal
                             domain of another fibrin (By similarity).
COILED      149    213       Potential.
SITE         34     35       Cleavage; by thrombin; to release
                             fibrinopeptide B (By similarity).
CARBOHYD    384    384       N-linked (GlcNAc...) (Potential).
DISULFID    213    213       Interchain (with alpha chain) (By
                             similarity).
DISULFID    217    217       Interchain (with gamma chain) (By
                             similarity).
DISULFID    221    306       By similarity.
DISULFID    231    260       By similarity.
DISULFID    414    427       By similarity.
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Nucleotide Sequence
Length: 1602 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 481 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Kcnma1IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
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