SMC protein 4SMC-4 Chromosome-associated polypeptide C; XCAP-C homolog;
Mus musculus (Mouse)
NCBI Taxonomy ID
View in Ensembl genome browser
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
0.780375341 The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Abstract of related literatures
1. The SMC proteins are found in nearly all living organisms examined, where they play crucial roles in mitotic chromosome dynamics, regulation of gene expression, and DNA repair. We have explored the phylogenetic relationships of SMC proteins from prokaryotes and eukaryotes, as well as their relationship to similar ABC ATPases, using maximum-likelihood analyses. We have also investigated the coevolution of different domains of eukaryotic SMC proteins and attempted to account for the evolutionary patterns we have observed in terms of available structural data. Based on our analyses, we propose that each of the six eukaryotic SMC subfamilies originated through a series of ancient gene duplication events, with the condensins evolving more rapidly than the cohesins. In addition, we show that the SMC5 and SMC6 subfamily members have evolved comparatively rapidly and suggest that these proteins may perform redundant functions in higher eukaryotes. Finally, we propose a possible structure for the SMC5/SMC6 heterodimer based on patterns of coevolution. PMID: 
2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: 
3. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: 
Central component of the condensin complex, a complexrequired for conversion of interphase chromatin into mitotic-likecondense chromosomes. The condensin complex probably introducespositive supercoils into relaxed DNA in the presence of type Itopoisomerases and converts nicked DNA into positive knotted formsin the presence of type II topoisomerases (By similarity).
Nucleus (By similarity). Cytoplasm (Bysimilarity). Chromosome (By similarity). Note=In interphase cells,the majority of the condensin complex is found in the cytoplasm,while a minority of the complex is associated with chromatin. Asubpopulation of the complex however remains associated withchromosome foci in interphase cells. During mitosis, most of thecondensin complex is associated with the chromatin. At the onsetof prophase, the regulatory subunits of the complex arephosphorylated by CDC2, leading to condensin's association withchromosome arms and to chromosome condensation. Dissociation fromchromosomes is observed in late telophase (By similarity).