Tag Content
SG ID
SG00013145 
UniProt Accession
Theoretical PI
8.81  
Molecular Weight
27866 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Psma8 
Gene Synonyms/Alias
Psma7l 
Protein Name
Proteasome subunit alpha type-7-like 
Protein Synonyms/Alias
EC=3.4.25.1 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:18;14864660-14920808;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.795994198 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
The proteasome is a multicatalytic proteinase complexwhich is characterized by its ability to cleave peptides with Arg,Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral orslightly basic pH. The proteasome has an ATP-dependent proteolyticactivity (By similarity). This may be a testis-specific subunit. 
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Subcellular Location
Cytoplasm (By similarity). Nucleus (Bysimilarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell.
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0019773 C:proteasome core complex, alpha-subunit complex IEA:InterPro.
GO:0004298 F:threonine-type endopeptidase activity IEA:UniProtKB-KW.
GO:0006511 P:ubiquitin-dependent protein catabolic process IEA:InterPro.
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Interpro
IPR000426;    Proteasome_asu_N.
IPR023332;    Proteasome_suA-type.
IPR001353;    Proteasome_sua/b.
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Pfam
PF00227;    Proteasome;    1.
PF10584;    Proteasome_A_N;    1.
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SMART
SM00948;    Proteasome_A_N;    1.
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PROSITE
PS00388;    PROTEASOME_A_1;    1.
PS51475;    PROTEASOME_A_2;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    250       Proteasome subunit alpha type-7-like.
                             /FTId=PRO_0000124150.
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Nucleotide Sequence
Length: 1695 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 250 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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