Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
101813 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
Patched domain-containing protein 3 
Protein Synonyms/Alias
RND-type protein RNDEu-3; 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

2. The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the availability of a finished, high-quality genome assembly. The finished clone-based assembly of the mouse strain C57BL/6J reported here has over 175,000 fewer gaps and over 139 Mb more of novel sequence, compared with the earlier MGSCv3 draft genome assembly. In a comprehensive analysis of this revised genome sequence, we are now able to define 20,210 protein-coding genes, over a thousand more than predicted in the human genome (19,042 genes). In addition, we identified 439 long, non-protein-coding RNAs with evidence for transcribed orthologs in human. We analyzed the complex and repetitive landscape of 267 Mb of sequence that was missing or misassembled in the previously published assembly, and we provide insights into the reasons for its resistance to sequencing and assembly by whole-genome shotgun approaches. Duplicated regions within newly assembled sequence tend to be of more recent ancestry than duplicates in the published draft, correcting our initial understanding of recent evolution on the mouse lineage. These duplicates appear to be largely composed of sequence regions containing transposable elements and duplicated protein-coding genes; of these, some may be fixed in the mouse population, but at least 40% of segmentally duplicated sequences are copy number variable even among laboratory mouse strains. Mouse lineage-specific regions contain 3,767 genes drawn mainly from rapidly-changing gene families associated with reproductive functions. The finished mouse genome assembly, therefore, greatly improves our understanding of rodent-specific biology and allows the delineation of ancestral biological functions that are shared with human from derived functions that are not. PMID: [19468303] 

3. The Hedgehog (Hh) signaling pathway plays an important role in various biological processes, including pattern formation, cell fate determination, proliferation, and differentiation. Hh function is mediated through its membrane receptor Patched. Herein, we have characterized a novel Patched-domain containing gene Ptchd3 in mouse. Messenger RNA of Ptchd3 was exclusively detected in the testis, and existed in two isoforms Ptchd3a and Ptchd3b. The expression of these two mRNA isoforms was shown to be developmentally regulated in testes, and specifically found in male germ cells. Further analysis revealed that the Ptchd3 protein was located on the midpiece of mouse, rat and human sperm. Collectively, these results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function. PMID: [17904097] 

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May play a role in sperm development or sperm function. 
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Subcellular Location
Membrane; Multi-pass membrane protein(Potential). Note=Localizes to the midpiece of the sperm tail. 
Tissue Specificity
Expressed in germ cells of the testis (atprotein level). 
Gene Ontology
GO IDGO termEvidence
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0008158 F:hedgehog receptor activity IEA:InterPro.
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IPR003392;    Patched.
IPR000731;    SSD.
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PF02460;    Patched;    1.
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PS50156;    SSD;    1.
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    906       Patched domain-containing protein 3.
TRANSMEM    338    358       Helical; (Potential).
TRANSMEM    370    390       Helical; (Potential).
TRANSMEM    392    412       Helical; (Potential).
TRANSMEM    442    462       Helical; (Potential).
TRANSMEM    476    496       Helical; (Potential).
TRANSMEM    559    579       Helical; (Potential).
TRANSMEM    760    780       Helical; (Potential).
TRANSMEM    782    802       Helical; (Potential).
TRANSMEM    814    834       Helical; (Potential).
TRANSMEM    848    868       Helical; (Potential).
TRANSMEM    883    903       Helical; (Potential).
DOMAIN      339    496       SSD.
CARBOHYD    148    148       N-linked (GlcNAc...) (Potential).
CARBOHYD    235    235       N-linked (GlcNAc...) (Potential).
VAR_SEQ     410    410       V -> E (in isoform 2).
VAR_SEQ     411    906       Missing (in isoform 2).
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Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 906 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data