SG ID

SG00018205 

UniProt Accession

ATIF1_MOUSE;O35143;Q9D879;  

Theoretical PI

9.3  

Molecular Weight

12159 Da  

Genbank Nucleotide ID

AF002718; AK008346; AK152389; AL805897; CH466552; BC012680;  

Genbank Protein ID

AAB69647.1; BAB25618.1; BAE31177.1; CAM26517.1; EDL30101.1; AAH12680.1; 

Gene Name

Atpif1 

Gene Synonyms/Alias

Atpi, If1 

Protein Name

ATPase inhibitor, mitochondrial 

Protein Synonyms/Alias

Inhibitor of F(1)F(o)-ATPase;IF(1)IF1Flags: Precursor 

Mus musculus (Mouse) 

10090 

Uncertain 

Uncertain 

0.645000572 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.

Temporarily unavailable 

Abstract of related literatures

1. The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the availability of a finished, high-quality genome assembly. The finished clone-based assembly of the mouse strain C57BL/6J reported here has over 175,000 fewer gaps and over 139 Mb more of novel sequence, compared with the earlier MGSCv3 draft genome assembly. In a comprehensive analysis of this revised genome sequence, we are now able to define 20,210 protein-coding genes, over a thousand more than predicted in the human genome (19,042 genes). In addition, we identified 439 long, non-protein-coding RNAs with evidence for transcribed orthologs in human. We analyzed the complex and repetitive landscape of 267 Mb of sequence that was missing or misassembled in the previously published assembly, and we provide insights into the reasons for its resistance to sequencing and assembly by whole-genome shotgun approaches. Duplicated regions within newly assembled sequence tend to be of more recent ancestry than duplicates in the published draft, correcting our initial understanding of recent evolution on the mouse lineage. These duplicates appear to be largely composed of sequence regions containing transposable elements and duplicated protein-coding genes; of these, some may be fixed in the mouse population, but at least 40% of segmentally duplicated sequences are copy number variable even among laboratory mouse strains. Mouse lineage-specific regions contain 3,767 genes drawn mainly from rapidly-changing gene families associated with reproductive functions. The finished mouse genome assembly, therefore, greatly improves our understanding of rodent-specific biology and allows the delineation of ancestral biological functions that are shared with human from derived functions that are not. PMID: [19468303] 

Function

Endogenous F(1)F(o)-ATPase inhibitor limiting ATPdepletion when the mitochondrial membrane potential falls below athreshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP topump protons out of the mitochondrial matrix. 

Subcellular Location

Mitochondrion. 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0009986	C:cell surface	ISS:UniProtKB.
GO:0005739	C:mitochondrion	ISS:UniProtKB.
GO:0042030	F:ATPase inhibitor activity	ISS:UniProtKB.
GO:0001937	P:negative regulation of endothelial cell proliferation	ISS:UniProtKB.
GO:0051346	P:negative regulation of hydrolase activity	ISS:UniProtKB.
GO:0045980	P:negative regulation of nucleotide metabolic process	IEA:InterPro.
GO:0051289	P:protein homotetramerization	ISS:UniProtKB.

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Interpro

IPR007648;    ATPase_inhibitor_IATP_mt.
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Pfam

PF04568;    IATP;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

GAS predicted 

Sequence Annotation

Nucleotide Sequence

Length: 509 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 106 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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