SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00018701 
UniProt Accession
Theoretical PI
6.33  
Molecular Weight
38222 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Pcbp2 
Gene Synonyms/Alias
Cbp, Hnrnpx, Hnrpx 
Protein Name
Poly(rC)-binding protein 2 
Protein Synonyms/Alias
Alpha-CP2; CTBP;CBP Putative heterogeneous nuclear ribonucleoprotein X;hnRNP X 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:15;102301063-102330490;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.672916165 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
2. Two single-stranded nucleic acid binding proteins mCBP and mCTBP were identified by means of their binding to a potential recombination hotspot in LTRs of mouse retro-transposons. Both are nuclear proteins of 35 and 55 kDa respectively. mCBP binds preferentially to oligo dC, mCTBP to oligo dCdT. mCBP was purified and its cDNA was isolated and sequenced. PMID: [8208614] 

3. We have identified two novel human genes encoding proteins with a high level of sequence identity to two previously characterized RNA-binding proteins, alphaCP-1 and alphaCP-2. Both of these novel genes, alphaCP-3 and alphaCP-4, are predicted to encode proteins with triplicated KH domains. The number and organization of the KH domains, their sequences, and the sequences of the contiguous regions are conserved among all four alphaCP proteins. The common evolutionary origin of these proteins is substantiated by conservation of exon-intron organization in the corresponding genes. The map positions of alphaCP-1 and alphaCP-2 (previously reported) and those of alphaCP-3 and alphaCP-4 (present report) reveal that the four alphaCP loci are dispersed in the human genome; alphaCP-3 and alphaCP-4 mapped to 21q22.3 and 3p21, and the respective mouse orthologues mapped to syntenic regions of the mouse genome, 10B5 and 9F1-F2, respectively. Two additional loci in the human genome were identified as alphaCP-2 processed pseudogenes (PCBP2P1, 21q22.3, and PCBP2P2, 8q21-q22). Although the overall levels of alphaCP-3 and alphaCP-4 mRNAs are substantially lower than those of alphaCP-1 and alphaCP-2, transcripts of alphaCP-3 and alphaCP-4 were found in all mouse tissues tested. These data establish a new subfamily of genes predicted to encode closely related KH-containing RNA-binding proteins with potential functions in posttranscriptional controls. PMID: [10936052] 

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Function
Single-stranded nucleic acid binding protein that bindspreferentially to oligo dC. Major cellular poly(rC)-bindingprotein. Binds also poly(rU). Negatively regulates cellularantiviral responses mediated by MAVS signaling. It acts as anadapter between MAVS and the E3 ubiquitin ligase ITCH, thereforetriggering MAVS ubiquitinationa and degradation (By similarity). 
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Subcellular Location
Nucleus (By similarity). Cytoplasm (Bysimilarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell.
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0030529 C:ribonucleoprotein complex IEA:UniProtKB-KW.
GO:0003677 F:DNA binding IEA:UniProtKB-KW.
GO:0003723 F:RNA binding IEA:UniProtKB-KW.
GO:0045087 P:innate immune response IEA:UniProtKB-KW.
GO:0050687 P:negative regulation of defense response to virus ISS:UniProtKB.
GO:0043161 P:proteasomal ubiquitin-dependent protein catabolic process ISS:UniProtKB.
GO:0009615 P:response to virus IEA:UniProtKB-KW.
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Interpro
IPR004087;    KH_dom.
IPR004088;    KH_dom_type_1.
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Pfam
PF00013;    KH_1;    3.
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SMART
SM00322;    KH;    3.
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PROSITE
PS50084;    KH_TYPE_1;    3.
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PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    362       Poly(rC)-binding protein 2.
                             /FTId=PRO_0000050091.
DOMAIN       13     75       KH 1.
DOMAIN       97    162       KH 2.
DOMAIN      284    348       KH 3.
MOD_RES     169    169       Phosphoserine (By similarity).
MOD_RES     183    183       Phosphoserine (By similarity).
MOD_RES     185    185       Phosphoserine (By similarity).
MOD_RES     232    232       Phosphotyrosine (By similarity).
MOD_RES     268    268       Phosphoserine (By similarity).
VAR_SEQ     194    224       Missing (in isoform 2).
                             /FTId=VSP_002820.
VAR_SEQ     263    275       Missing (in isoform 3).
                             /FTId=VSP_002821.
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Nucleotide Sequence
Length: 1472 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 362 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
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