Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
36912 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
Fructose-1,6-bisphosphatase 1 
Protein Synonyms/Alias
FBPase 1EC= D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. A cDNA encoding fructose-1,6-bisphosphatase (FBPase) was isolated from mouse liver RNA. The cDNA encodes a polypeptide of 338 amino acids (36.9 kDa). The liver and muscle FBPase isoenzymes of the mouse show positional identities of 69% at the cDNA level and 72% at the protein primary structure level. Starting from genomic YAC libraries and based upon the cDNA sequence all functional parts of the mouse liver FBPase gene (including exon-intron boundaries) were PCR-amplified and sequenced. The 5'-flanking regions of the liver and muscle FBPase genes were compared and showed no sequence similarity. Both genes are co-localized at chromosome 13B3-C1. The transcriptional start site was assigned to a guanine 118 bases before the start codon in the liver FBPase gene. An analysis of the steady state mRNA levels of liver and muscle FBPase in various mouse tissues was performed by Northern blotting and RT/PCR. PMID: [11250076] 

2. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

3. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Subcellular Location
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0005829 C:cytosol ISS:UniProtKB.
GO:0005625 C:soluble fraction IEA:Compara.
GO:0016208 F:AMP binding ISS:UniProtKB.
GO:0042132 F:fructose 1,6-bisphosphate 1-phosphatase activity ISS:UniProtKB.
GO:0046872 F:metal ion binding ISS:UniProtKB.
GO:0048029 F:monosaccharide binding ISS:UniProtKB.
GO:0035690 P:cellular response to drug ISS:UniProtKB.
GO:0032869 P:cellular response to insulin stimulus IEA:Compara.
GO:0071286 P:cellular response to magnesium ion ISS:UniProtKB.
GO:0006002 P:fructose 6-phosphate metabolic process ISS:UniProtKB.
GO:0006094 P:gluconeogenesis ISS:UniProtKB.
GO:0030308 P:negative regulation of cell growth ISS:UniProtKB.
GO:0045820 P:negative regulation of glycolysis ISS:UniProtKB.
GO:0046580 P:negative regulation of Ras protein signal transduction ISS:UniProtKB.
GO:0051289 P:protein homotetramerization ISS:UniProtKB.
GO:0006111 P:regulation of gluconeogenesis ISS:UniProtKB.
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IPR000146;    FBPase_class-1/SBPase.
IPR020548;    Fructose_bisphosphatase_AS.
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PF00316;    FBPase;    1.
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PS00124;    FBPASE;    1.
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PR00115;    F16BPHPHTASE.;   
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Created Date
Record Type
GAS predicted 
Sequence Annotation
INIT_MET      1      1       Removed (By similarity).
CHAIN         2    338       Fructose-1,6-bisphosphatase 1.
NP_BIND      18     22       AMP (By similarity).
NP_BIND      28     32       AMP (By similarity).
NP_BIND     113    114       AMP (By similarity).
REGION      122    125       Substrate binding (By similarity).
REGION      213    216       Substrate binding (By similarity).
REGION      244    249       Substrate binding (By similarity).
REGION      275    277       Substrate binding (By similarity).
METAL        69     69       Magnesium 1 (By similarity).
METAL        98     98       Magnesium 1 (By similarity).
METAL        98     98       Magnesium 2 (By similarity).
METAL       119    119       Magnesium 2 (By similarity).
METAL       119    119       Magnesium 3 (By similarity).
METAL       121    121       Magnesium 2; via carbonyl oxygen (By
METAL       122    122       Magnesium 3 (By similarity).
METAL       281    281       Magnesium 3 (By similarity).
BINDING     141    141       AMP (By similarity).
BINDING     265    265       Substrate (By similarity).
MOD_RES       2      2       N-acetylalanine (By similarity).
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Nucleotide Sequence
Length: 1452 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 338 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
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