Tag Content
UniProt Accession
Theoretical PI
Molecular Weight
26223 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Gene Synonyms/Alias
Protein Name
StAR-related lipid transfer protein 6 
Protein Synonyms/Alias
START domain-containing protein 6;StARD6 
Mus musculus (Mouse) 
NCBI Taxonomy ID
Chromosome Location
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Probability (GAS) of Function in Spermatogenesis
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Temporarily unavailable 
Abstract of related literatures
1. Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet. StarD4 expression in cultured 3T3 cells was also sterol-regulated, and known sterol regulatory element binding protein (SREBP)-target genes showed coordinate regulation. The closest homologues to StarD4 were two other StAR-related lipid transfer (START) proteins named StarD5 and StarD6. StarD4, StarD5, and StarD6 are 205- to 233-aa proteins consisting almost entirely of START domains. These three constitute a subfamily among START proteins, sharing approximately 30% amino acid identity with one another, approximately 20% identity with the cholesterol-binding START domains of StAR and MLN64, and less than 15% identity with phosphatidylcholine transfer protein (PCTP) and other START domains. StarD4 and StarD5 were expressed in most tissues, with highest levels in liver and kidney, whereas StarD6 was expressed exclusively in the testis. In contrast to StarD4, expression of StarD5 and MLN64 was not sterol-regulated. StarD4, StarD5, and StarD6 may be involved in the intracellular transport of sterols or other lipids. PMID: [12011452] 

2. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

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May be involved in the intracellular transport ofsterols or other lipids. May bind cholesterol or other sterols (Bysimilarity). 
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Subcellular Location
Tissue Specificity
Gene Ontology
GO IDGO termEvidence
GO:0015485 F:cholesterol binding ISA:MGI.
GO:0017127 F:cholesterol transporter activity IEA:InterPro.
GO:0030301 P:cholesterol transport IEA:GOC.
GO:0006694 P:steroid biosynthetic process IEA:InterPro.
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IPR000799;    StAR.
IPR023393;    START-like_dom.
IPR002913;    START_lipid-bd.
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PF01852;    START;    1.
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SM00234;    START;    1.
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PS50848;    START;    1.
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PR00978;    STARPROTEIN.;   
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Created Date
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    233       StAR-related lipid transfer protein 6.
DOMAIN        1    208       START.
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Nucleotide Sequence
Length: 702 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 233 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data