FertilityOnline | Spermatogenes

Detail Information of SG000080

General information

SG ID

SG000080

Gene Name

Zscan21

Gene Synonyms/Alias

AI326272, CTfin51, RU49, Zfp-38, Zfp38, Zipro1

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

ENSMUSG00000037017

Ensembl Protein ID

ENSMUSP00000053430 ENSMUSP00000106586 ENSMUSP00000079557 ENSMUSP00000106585
ENSMUSP00000121495 ENSMUSP00000119570 ENSMUSP00000106584

Description

Zinc finger and SCAN domain containing 21 [Mus musculus (house mouse)]

Orthology

Species	Uniprot	Gene stable ID	Gene Name
Rattus norvegicus	Q6AXN8	RGD:1309981	Zscan21
Danio rerio	A0A0R4IKB5	ZFIN:ZDB-GENE-050208-712	znf1155
Danio rerio	A0A0R4ISU2	ZFIN:ZDB-GENE-030131-3190	wu:fc30c06

More Orthology >>

Status

Reviewed functional gene

Functional information

Function in Stage	meiotic
Function in Cell Type	Spermatocyte
The information of related literature	1. Abstract The production of haploid gametes by meiosis is a cornerstone of sexual reproduction and maintenance of genome integrity. Zfp38 mRNA is expressed in spermatocytes, indicating that transcription factor ZFP38 has the ... PMID: [27492080]
Figures for illustrating the function of this protein/gene	Yan, Z., Fan, D., Meng, Q., Yang, J., Zhao, W., Guo, F., Song, D., Guo, R., Sun, K. and Wang, J. (2016) Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Reproduction 152(5): 431-7. PMID: [27492080] Yan, Z., Fan, D., Meng, Q., Yang, J., Zhao, W., Guo, F., Song, D., Guo, R., Sun, K. and Wang, J. (2016) Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Reproduction 152(5): 431-7. PMID: [27492080] Yan, Z., Fan, D., Meng, Q., Yang, J., Zhao, W., Guo, F., Song, D., Guo, R., Sun, K. and Wang, J. (2016) Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Reproduction 152(5): 431-7. PMID: [27492080] Yan, Z., Fan, D., Meng, Q., Yang, J., Zhao, W., Guo, F., Song, D., Guo, R., Sun, K. and Wang, J. (2016) Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Reproduction 152(5): 431-7. PMID: [27492080] Yan, Z., Fan, D., Meng, Q., Yang, J., Zhao, W., Guo, F., Song, D., Guo, R., Sun, K. and Wang, J. (2016) Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Reproduction 152(5): 431-7. PMID: [27492080]
Functional description	ZFP38 is a novel spermatocyte factor required for progression of meiotic prophase I in male mice. Although Zfp38 transcripts was expressed from pachytene spermatocytes to round spermatids, ZFP38 protein was undetectable in round spermatids. ZFP38 is critical for the chromosomal synapsis and DSB repairs partially via its regulation of DSB repair-associated protein expression during meiotic progression in mouse\|ZFP38 is transcription factor essential for meiosis prophase I in male mice. ZFP38 is critical for the chromosomal synapsis and DSB repairs partially via its regulation of DSB repair-associated protein expression during meiotic progression in mouse
Protein complex
Pathway
Human diseases
OMIM
Spermatogenesis failure	SDA

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatocyte
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Nucleus.

Mutation in human orthology

Variants founded in public databases

1000G (Phase 3): 409 ESP6500 (SI-V2): 80 ExAC (r0.3.1): 343 dbSNP(Build 147): 1102

Variants founded in in-house datasets

Chinese health control (254): 4 European health control (283): 2 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
ZSCAN21	0.0000191925	0.0000202214

Other information

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0006351	transcription, DNA-templated	IEA
Biological Process	GO:0006355	regulation of transcription, DNA-templated	ISO
Biological Process	GO:0006366	transcription from RNA polymerase II promoter	IEA
Biological Process	GO:0007275	multicellular organism development	IEA
Biological Process	GO:0007283	spermatogenesis	IEA
Biological Process	GO:0030154	cell differentiation	IEA
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISO
Biological Process	GO:0048477	oogenesis	IEA
Cellular Component	GO:0005634	nucleus	IDA
Molecular Function	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	ISO
Molecular Function	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	ISO
Molecular Function	GO:0003676	nucleic acid binding	IEA
Molecular Function	GO:0003677	DNA binding	IDA
Molecular Function	GO:0003700	transcription factor activity, sequence-specific DNA binding	IEA
Molecular Function	GO:0046872	metal ion binding	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000053430	Zscan21	ENSMUSP00000053597	Lrrc38	experimental
ENSMUSP00000053430	Zscan21	ENSMUSP00000053641	Foxi2	experimental
ENSMUSP00000053430	Zscan21	ENSMUSP00000053644		experimental

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Protein family and Domain

Q07231