SpermatogenesisOnline 1.0

Tag Content
SG ID
SG00017766 
UniProt Accession
Theoretical PI
7.68  
Molecular Weight
28979 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Taf9 
Gene Synonyms/Alias
Taf2g 
Protein Name
Transcription initiation factor TFIID subunit 9 
Protein Synonyms/Alias
RNA polymerase II TBP-associated factor subunit G; Transcription initiation factor TFIID 31 kDa subunit;TAFII-31TAFII31 Transcription initiation factor TFIID 32 kDa subunit;TAFII-32TAFII32 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:13;101421298-101426014;1
View in Ensembl genome browser  
Function in Stage
Uncertain 
Function in Cell Type
Uncertain 
Probability (GAS) of Function in Spermatogenesis
0.983735368 
The probability was calculated by GAS algorithm, ranging from 0 to 1. The closer it is to 1, the more possibly it functions in spermatogenesis.
Description
Temporarily unavailable 
Abstract of related literatures
1. This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. PMID: [16141072] 

2. The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline. PMID: [15489334] 

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Function
Essential for cell viability. TAF9 and TAF9B areinvolved in transcriptional activation as well as repression ofdistinct but overlapping sets of genes. May have a role in generegulation associated with apoptosis. TAFs are components of thetranscription factor IID (TFIID) complex, the TBP-free TAFIIcomplex (TFTC), the PCAF histone acetylase complex and the STAGAtranscription coactivator-HAT complex. TFIID or TFTC are essentialfor the regulation of RNA polymerase II-mediated transcription (Bysimilarity). 
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Subcellular Location
Nucleus (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0071339 C:MLL1 complex ISS:UniProtKB.
GO:0000125 C:PCAF complex IEA:Compara.
GO:0070761 C:pre-snoRNP complex IEA:Compara.
GO:0030914 C:STAGA complex IEA:Compara.
GO:0005669 C:transcription factor TFIID complex ISO:MGI.
GO:0033276 C:transcription factor TFTC complex IEA:Compara.
GO:0003677 F:DNA binding IDA:MGI.
GO:0004402 F:histone acetyltransferase activity IEA:Compara.
GO:0003713 F:transcription coactivator activity IEA:Compara.
GO:0044212 F:transcription regulatory region DNA binding IEA:Compara.
GO:0006352 P:DNA-dependent transcription, initiation IEA:InterPro.
GO:0043966 P:histone H3 acetylation IEA:Compara.
GO:0043066 P:negative regulation of apoptotic process IEA:Compara.
GO:0032435 P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA:Compara.
GO:0030307 P:positive regulation of cell growth IEA:Compara.
GO:0060760 P:positive regulation of response to cytokine stimulus IEA:Compara.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter IMP:BHF-UCL.
GO:0070555 P:response to interleukin-1 IEA:Compara.
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Interpro
IPR009072;    Histone-fold.
IPR003162;    TFIID-31.
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Pfam
PF02291;    TFIID-31kDa;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
GAS predicted 
Sequence Annotation
CHAIN         1    264       Transcription initiation factor TFIID
                             subunit 9.
                             /FTId=PRO_0000118889.
COMPBIAS    248    262       Poly-Asp.
MOD_RES       5      5       N6-acetyllysine (By similarity).
MOD_RES      85     85       Phosphoserine (By similarity).
MOD_RES     108    108       N6-acetyllysine (By similarity).
MOD_RES     149    149       Phosphoserine (By similarity).
MOD_RES     155    155       Phosphoserine (By similarity).
MOD_RES     158    158       Phosphoserine (By similarity).
MOD_RES     159    159       Phosphothreonine (By similarity).
MOD_RES     161    161       Phosphothreonine (By similarity).
MOD_RES     178    178       Phosphothreonine (By similarity).
MOD_RES     181    181       Phosphoserine (By similarity).
CONFLICT    161    161       T -> P (in Ref. 3; AAH43028).
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Nucleotide Sequence
Length: 1137 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 264 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
EsrrbBioGRID 
EsrrbBioGRID 
Kat2aIntAct 
EsrrbBioGRID 
EsrrbBioGRID 
Klf1DIP 
Other Protein-Protein interaction resources
String database  
View Microarray data
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