FertilityOnline | Spermatogenes

Detail Information of SG000085

General information

SG ID

SG000085

Gene Name

Glis3

Gene Synonyms/Alias

4833409N03Rik, E330013K21Rik

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

ENSMUSG00000052942

Ensembl Protein ID

ENSMUSP00000124635 ENSMUSP00000108231 ENSMUSP00000066953 ENSMUSP00000124143
ENSMUSP00000125721 ENSMUSP00000124823

Description

GLIS family zinc finger 3 [Mus musculus (house mouse)]

Orthology

Species	Uniprot	Gene stable ID	Gene Name
Rattus norvegicus	D4A314	RGD:1565505	Glis3
Gallus gallus	E1C1Q5	Ensembl:ENSGALG00000010180	GLIS3
Danio rerio	A0A0R4IU95	ZFIN:ZDB-GENE-070112-2232	glis3

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Status

Reviewed functional gene

Functional information

Function in Stage	premeiotic
Function in Cell Type	Gonocyte
The information of related literature	1. Abstract In this study, we identify a novel and essential role for the Kruppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) in the regulation of postnatal spermatogenesis. We show that GLIS3 is ... PMID: [27350140]
Figures for illustrating the function of this protein/gene	Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140] Kang, H. S., Chen, L. Y., Lichti-Kaiser, K., Liao, G., Gerrish, K., Bortner, C. D., Yao, H. H., Eddy, E. M. and Jetten, A. M. (2016) Transcription Factor GLIS3. Stem Cells (): . PMID: [27350140]
Functional description	Kruppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) is expressed in gonocytes, spermatogonial stem cells (SSCs) and spermatogonial progenitors (SPCs), but not in differentiated spermatogonia and later stages of spermatogenesis or in somatic cells. Loss of GLIS3 function causes a moderate reduction in the number of gonocytes, but greatly affects the generation of SSCs/SPCs, and as a consequence the development of spermatocytes
Protein complex
Pathway
Human diseases
OMIM
Spermatogenesis failure	SCO

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in thyroid gland
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatogonium
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Nucleus

Mutation in human orthology

Variants founded in public databases

1000G (Phase 3): 19885 ESP6500 (SI-V2): 227 ExAC (r0.3.1): 1176 dbSNP(Build 147): 37566

Variants founded in in-house datasets

Chinese health control (254): 30 European health control (283): 24 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
GLIS3	0.0000439	0.000049963

Other information

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
Biological Process	GO:0006351	transcription, DNA-templated	IEA
Biological Process	GO:0006355	regulation of transcription, DNA-templated	IEA
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA
Biological Process	GO:0006366	transcription from RNA polymerase II promoter	IDA
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA
Cellular Component	GO:0005634	nucleus	IEA
Molecular Function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
Molecular Function	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA
Molecular Function	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	IDA
Molecular Function	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	IDA
Molecular Function	GO:0003676	nucleic acid binding	IEA
Molecular Function	GO:0003677	DNA binding	IDA
Molecular Function	GO:0003700	transcription factor activity, sequence-specific DNA binding	IDA
Molecular Function	GO:0046872	metal ion binding	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000124635	Glis3	ENSMUSP00000124674	Kif6	experimental
ENSMUSP00000124635	Glis3	ENSMUSP00000124709	Grip2	experimental
ENSMUSP00000124635	Glis3	ENSMUSP00000124804	Nwd1	experimental

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Protein family and Domain

Q6XP49