Detail Information of SG000124


General information  

SG000124
Cul4b
2700050M05Rik, AA409770, CUL-4B, mKIAA0695
Mus musculus
10090
ENSMUSG00000031095
ENSMUSP00000016681  ENSMUSP00000110771  ENSMUSP00000136083  ENSMUSP00000059276  

Cullin 4B [Mus musculus (house mouse)]

SpeciesUniprotGene stable IDGene Name
Rattus norvegicusD3ZK73RGD:1564494Cul4b
Gallus gallusE1BQK9Ensembl:ENSGALG00000008559CUL4B
Danio rerioF1R029ZFIN:ZDB-GENE-041008-208cul4b
  More Orthology >>

Reviewed functional gene

Functional information  

premeiotic    meiotic    postmeiotic    
Sertoli cell    Spermatid    Spermatocyte    

1. Abstract
CUL4B ubiquitin ligase belongs to the cullin-RING ubiquitin ligase family. Although sharing many sequence and structural similarities, CUL4B plays distinct roles in spermatogenesis from its homologous protein CUL4A. We previously reported ... PMID: [26846852]  

2. Abstract
In this study, we demonstrate that an E3-ubiquitin ligase associated with human X-linked intellectual disability, CUL4B, plays a crucial role in post-meiotic sperm development. Initially, Cul4b(Delta)/Y male mice were found to be ... PMID: [26832838]  

Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852]

Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852]

Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852]

Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852]

Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852]

Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838]

CUL4B ubiquitin ligase belongs to the cullin-RING ubiquitin ligase family that plays distinct roles in spermatogenesis from its homologous protein CUL4A. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis. CUL4B, plays a crucial role in post-meiotic sperm development
 
ReactomeID: R-MMU-8951664
Neddylation
N/A

Expression and location  

Expressed highest in testis
Expressed highest in sertoli cell
View detail
View detail
Nucleus

Mutation in human orthology  

1000G (Phase 3): 981   ESP6500 (SI-V2): 109   ExAC (r0.3.1): 471   dbSNP(Build 147): 2141

Chinese health control (254): 3  European health control (283):     Chinese patients (168):  

Gene NameDNMR-averageDNMR-SC
CUL4B0.000032130.0000322409

Other information  

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Sub-OntologiesAccessionTermEvidence
Biological ProcessGO:0006281DNA repairIEA
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processIEA
Biological ProcessGO:0006974cellular response to DNA damage stimulusIEA
Biological ProcessGO:0007049cell cycleIEA
Biological ProcessGO:0016567protein ubiquitinationIEA
Biological ProcessGO:0031175neuron projection developmentIEA
Biological ProcessGO:0035518histone H2A monoubiquitinationIEA
Biological ProcessGO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic processIBA
Biological ProcessGO:0045732positive regulation of protein catabolic processIMP
Biological ProcessGO:0070914UV-damage excision repairIEA
Biological ProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleIMP
Cellular ComponentGO:0005634nucleusIEA
Cellular ComponentGO:0005654nucleoplasmIEA
Cellular ComponentGO:0005829cytosolIEA
Cellular ComponentGO:0031461cullin-RING ubiquitin ligase complexIEA
Cellular ComponentGO:0031465Cul4B-RING E3 ubiquitin ligase complexIEA
Cellular ComponentGO:0070062extracellular exosomeIEA
Molecular FunctionGO:0003684damaged DNA bindingIEA
Molecular FunctionGO:0031625ubiquitin protein ligase bindingIEA
Molecular FunctionGO:0061630ubiquitin protein ligase activityIBA
Protein AGene name AProtein BGene name BEvidence
ENSMUSP00000059276Cul4bENSMUSP00000059289Nup160predicted
ENSMUSP00000059276Cul4bENSMUSP00000059385Nipblpredicted
ENSMUSP00000059276Cul4bENSMUSP00000059395Eif2s3xpredicted
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A2A432