SG000124 | |||||||||||||||||
Cul4b | |||||||||||||||||
2700050M05Rik, AA409770, CUL-4B, mKIAA0695 | |||||||||||||||||
Mus musculus | |||||||||||||||||
10090 | |||||||||||||||||
ENSMUSG00000031095 | |||||||||||||||||
ENSMUSP00000016681 ENSMUSP00000110771 ENSMUSP00000136083 ENSMUSP00000059276 | |||||||||||||||||
Cullin 4B [Mus musculus (house mouse)] | |||||||||||||||||
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Reviewed functional gene |
premeiotic meiotic postmeiotic | |
Sertoli cell Spermatid Spermatocyte | |
1. Abstract 2. Abstract | |
Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852] Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852] Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852] Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852] Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852] Yin, Y., Liu, L., Yang, C., Lin, C., Veith, G. M., Wang, C., Sutovsky, P., Zhou, P. and Ma, L. (2016) Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem 291(13): 6923-35. PMID: [26846852] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] Lin, C. Y., Chen, C. Y., Yu, C. H., Yu, I. S., Lin, S. R., Wu, J. T., Lin, Y. H., Kuo, P. L., Wu, J. C. and Lin, S. W. (2016) Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep 6(): 20227. PMID: [26832838] | |
CUL4B ubiquitin ligase belongs to the cullin-RING ubiquitin ligase family that plays distinct roles in spermatogenesis from its homologous protein CUL4A. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis. CUL4B, plays a crucial role in post-meiotic sperm development | |
ReactomeID: R-MMU-8951664 Neddylation | |
N/A |
Expressed highest in testis | |
Expressed highest in sertoli cell | |
View detail | |
View detail | |
Nucleus |
1000G (Phase 3): 981 ESP6500 (SI-V2): 109 ExAC (r0.3.1): 471 dbSNP(Build 147): 2141 |
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Chinese health control (254): 3 European health control (283): Chinese patients (168): |
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A2A432 |