FertilityOnline | Spermatogenes

Detail Information of SG000189

General information

SG ID	SG000189
Gene Name	Prmt5
Gene Synonyms/Alias	Jbp1, Skb1
Organism	Mus musculus
NCBI Taxonomy ID	10090
Ensembl Gene ID	ENSMUSG00000023110
Ensembl Protein ID	ENSMUSP00000023873 ENSMUSP00000121502 ENSMUSP00000138549
Description	Protein arginine N-methyltransferase 5 [Mus musculus (house mouse)]
Orthology
Status	Reviewed functional gene

Functional information

Function in Stage	meiotic
Function in Cell Type	Spermatocyte
The information of related literature	1. Abstract During germ cell development, epigenetic modifications undergo extensive remodeling. Abnormal epigenetic modifications usually result in germ cell loss and reproductive defect. Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which ... PMID: [26072710]
Figures for illustrating the function of this protein/gene	Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710] Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710] Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710] Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710] Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710] Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710] Wang, Y., Zhu, T., Li, Q., Liu, C., Han, F., Chen, M., Zhang, L., Cui, X., Qin, Y., Bao, S. and Gao, F. (2015) Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep 5(): 11031. PMID: [26072710]
Functional description	Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which has been demonstrated to play important roles in germ cell development during embryonic stages. Prmt5 was also abundantly expressed in male germ cells and Inactivation of this gene causes germ cell development block, loss of germ cells and reduction in the expression of meiosis associated genes.
Protein complex
Pathway	ReactomeID: R-MMU-6804760 Regulation of TP53 Activity through Methylation
Human diseases
OMIM
Spermatogenesis failure	N/A

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in thyroid gland
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatocyte
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Cytoplasm

Mutation in human orthology

Variants founded in public databases	1000G (Phase 3): ESP6500 (SI-V2): ExAC (r0.3.1): dbSNP(Build 147):
Variants founded in in-house datasets	Chinese health control (254): European health control (283): Chinese patients (168):
De novo Mutation Rate

Other information

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0000387	spliceosomal snRNP assembly	IEA
Biological Process	GO:0006353	DNA-templated transcription, termination	IEA
Biological Process	GO:0006479	protein methylation	IEA
Biological Process	GO:0018216	peptidyl-arginine methylation	IEA
Biological Process	GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine	IEA
Biological Process	GO:0032259	methylation	IEA
Biological Process	GO:0034969	histone arginine methylation	IEA
Biological Process	GO:0035246	peptidyl-arginine N-methylation	IEA
Biological Process	GO:0042118	endothelial cell activation	IEA
Biological Process	GO:0043985	histone H4-R3 methylation	IEA
Biological Process	GO:0044030	regulation of DNA methylation	IEA
Biological Process	GO:0045596	negative regulation of cell differentiation	IEA
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IEA
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	IEA
Biological Process	GO:0090161	Golgi ribbon formation	IEA
Biological Process	GO:0097421	liver regeneration	IEA
Biological Process	GO:1904992	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA
Cellular Component	GO:0005634	nucleus	IEA
Cellular Component	GO:0005737	cytoplasm	IEA
Cellular Component	GO:0005794	Golgi apparatus	IEA
Cellular Component	GO:0005829	cytosol	IEA
Cellular Component	GO:0034709	methylosome	IEA
Cellular Component	GO:0035097	histone methyltransferase complex	IEA
Cellular Component	GO:0043234	protein complex	IEA
Molecular Function	GO:0008168	methyltransferase activity	IEA
Molecular Function	GO:0008327	methyl-CpG binding	IEA
Molecular Function	GO:0008469	histone-arginine N-methyltransferase activity	IEA
Molecular Function	GO:0016274	protein-arginine N-methyltransferase activity	IEA
Molecular Function	GO:0016740	transferase activity	IEA
Molecular Function	GO:0032403	protein complex binding	IEA
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	IEA
Molecular Function	GO:0043021	ribonucleoprotein complex binding	IEA
Molecular Function	GO:0044020	histone methyltransferase activity (H4-R3 specific)	IEA
Molecular Function	GO:0046982	protein heterodimerization activity	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000023873	Prmt5	ENSMUSP00000024121	4921501E09Rik	predicted
ENSMUSP00000023873	Prmt5	ENSMUSP00000024518	Rhebl1	experimental
ENSMUSP00000023873	Prmt5	ENSMUSP00000024620	Chd1	predicted

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Protein family and Domain

A0A0R4J049