FertilityOnline | Spermatogenes

Detail Information of SG000299

General information

SG ID

SG000299

Gene Name

Cebpa

Gene Synonyms/Alias

C/ebpalpha, CBF-A, Cebp

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

ENSMUSG00000034957

Ensembl Protein ID

ENSMUSP00000145942 ENSMUSP00000096129

Description

CCAAT/enhancer binding protein (C/EBP), alpha [Mus musculus (house mouse)]

Orthology

Species	Uniprot	Gene stable ID	Gene Name
Rattus norvegicus	P05554	RGD:2326	Cebpa
Gallus gallus	R4GLL1	Ensembl:ENSGALG00000026525	-
Danio rerio	Q8UVZ1	ZFIN:ZDB-GENE-020111-2	cebpa

More Orthology >>

Status

Reviewed functional gene

Functional information

Function in Stage

postmeiotic

Function in Cell Type

Spermatid

The information of related literature

1. Abstract
During spermatogenesis, mRNA localization and translation are believed to be regulated in a stage-specific manner. We report here that the Protamine2 (Prm2) mRNA transits through chromatoid bodies of round spermatids and ... PMID: [24146628]

Figures for illustrating the function of this protein/gene

Fukuda, N., Fukuda, T., Sinnamon, J., Hernandez-Hernandez, A., Izadi, M., Raju, C. S., Czaplinski, K. and Percipalle, P. (2013) The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis. PLoS Genet 9(10): e1003858. PMID: [24146628]

Functional description

The transacting factor CBF-A, also termed Hnrnpab, contributes to temporal regulation of Prm2 translation. The Transacting Factor CBF-A/Hnrnpab Binds to the A2RE/RTS Element of Protamine 2 mRNA and Contributes to Its Translational Regulation during Mouse Spermatogenesis. CBF-A plays an important role in spermatogenesis by regulating stage-specific translation of testicular mRNAs.

Protein complex

Complex name	Subunits(UniProt IDs)	Functional comment
Cebpa-Smarca2 complex	P53566 O35846	The cEBP-alpha-Brm protein complex was detected in liver extracts from old isochronic parabionts but not from young isochronic parabionts.

Pathway

ReactomeID: R-MMU-442533
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes

Human diseases

OMIM

Spermatogenesis failure

N/A

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in adipose tissue
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatogonium
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Nucleus

Mutation in human orthology

Variants founded in public databases

1000G (Phase 3): 19 ESP6500 (SI-V2): 13 ExAC (r0.3.1): 79 dbSNP(Build 147): 113

Variants founded in in-house datasets

Chinese health control (254): European health control (283): Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
CEBPA	0.00002401225	0.00000928931

Other information

Click the right sign for more information

Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0000050	urea cycle	IDA
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
Biological Process	GO:0001889	liver development	IMP
Biological Process	GO:0001892	embryonic placenta development	IGI
Biological Process	GO:0006351	transcription, DNA-templated	IEA
Biological Process	GO:0006355	regulation of transcription, DNA-templated	IDA
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA
Biological Process	GO:0006360	transcription from RNA polymerase I promoter	ISO
Biological Process	GO:0006366	transcription from RNA polymerase II promoter	IEA
Biological Process	GO:0007005	mitochondrion organization	IMP
Biological Process	GO:0007219	Notch signaling pathway	IDA
Biological Process	GO:0007275	multicellular organism development	IEA
Biological Process	GO:0008203	cholesterol metabolic process	IMP
Biological Process	GO:0008285	negative regulation of cell proliferation	IDA
Biological Process	GO:0019221	cytokine-mediated signaling pathway	NAS
Biological Process	GO:0030099	myeloid cell differentiation	IDA
Biological Process	GO:0030225	macrophage differentiation	IMP
Biological Process	GO:0030324	lung development	IMP
Biological Process	GO:0030851	granulocyte differentiation	IDA
Biological Process	GO:0042127	regulation of cell proliferation	IMP
Biological Process	GO:0042593	glucose homeostasis	IMP
Biological Process	GO:0045444	fat cell differentiation	IDA
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IDA
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA
Biological Process	GO:0045786	negative regulation of cell cycle	IDA
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated	IDA
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA
Biological Process	GO:0045945	positive regulation of transcription from RNA polymerase III promoter	IEA
Biological Process	GO:0048469	cell maturation	IMP
Biological Process	GO:0048839	inner ear development	IDA
Biological Process	GO:0050872	white fat cell differentiation	IMP
Biological Process	GO:0050873	brown fat cell differentiation	IDA
Biological Process	GO:0055088	lipid homeostasis	IMP
Biological Process	GO:0071285	cellular response to lithium ion	IDA
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA
Cellular Component	GO:0005634	nucleus	IEA
Cellular Component	GO:0005654	nucleoplasm	TAS
Cellular Component	GO:0005667	transcription factor complex	IDA
Cellular Component	GO:0005730	nucleolus	ISO
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IEA
Cellular Component	GO:0090575	RNA polymerase II transcription factor complex	IEA
Molecular Function	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA
Molecular Function	GO:0001013	RNA polymerase I regulatory region DNA binding	ISO
Molecular Function	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	IDA
Molecular Function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	IEA
Molecular Function	GO:0003677	DNA binding	IDA
Molecular Function	GO:0003700	transcription factor activity, sequence-specific DNA binding	NAS
Molecular Function	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	IDA
Molecular Function	GO:0003713	transcription coactivator activity	IDA
Molecular Function	GO:0005515	protein binding	IPI
Molecular Function	GO:0008134	transcription factor binding	IEA
Molecular Function	GO:0019900	kinase binding	IPI
Molecular Function	GO:0042803	protein homodimerization activity	IDA
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA
Molecular Function	GO:0044212	transcription regulatory region DNA binding	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000096129	Cebpa	ENSMUSP00000096203		predicted
ENSMUSP00000096129	Cebpa	ENSMUSP00000096547	Smarca4	experimental
ENSMUSP00000096129	Cebpa	ENSMUSP00000096549	Elavl1	experimental

More PPIs >>

Protein family and Domain

P53566