FertilityOnline | Spermatogenes

Detail Information of SG000332

General information

SG ID

SG000332

Gene Name

Prss37

Gene Synonyms/Alias

1700016G05Rik, Tryx2

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

ENSMUSG00000029909

Ensembl Protein ID

ENSMUSP00000031967

Description

Protease, serine 37 [Mus musculus (house mouse)]

Orthology

Species	Uniprot	Gene stable ID	Gene Name
Rattus norvegicus	D4A527	RGD:1311823	Prss37

More Orthology >>

Status

Reviewed functional gene

Functional information

Function in Stage	postmeiotic
Function in Cell Type	Spermatid
The information of related literature	1. Abstract In order to understand the mechanisms of mammalian fertilization, studies using genetically manipulated animals have provided us with plenty of interesting and valuable information on the genetic factors affecting male fertility. In ... PMID: [23553430]
Figures for illustrating the function of this protein/gene	Shen, C., Kuang, Y., Liu, J., Feng, J., Chen, X., Wu, W., Chi, J., Tang, L., Wang, Y., Fei, J. and Wang, Z. (2013) Prss37 is required for male fertility in the mouse. Biol Reprod 88(5): 123. PMID: [23553430] Shen, C., Kuang, Y., Liu, J., Feng, J., Chen, X., Wu, W., Chi, J., Tang, L., Wang, Y., Fei, J. and Wang, Z. (2013) Prss37 is required for male fertility in the mouse. Biol Reprod 88(5): 123. PMID: [23553430] Shen, C., Kuang, Y., Liu, J., Feng, J., Chen, X., Wu, W., Chi, J., Tang, L., Wang, Y., Fei, J. and Wang, Z. (2013) Prss37 is required for male fertility in the mouse. Biol Reprod 88(5): 123. PMID: [23553430] Shen, C., Kuang, Y., Liu, J., Feng, J., Chen, X., Wu, W., Chi, J., Tang, L., Wang, Y., Fei, J. and Wang, Z. (2013) Prss37 is required for male fertility in the mouse. Biol Reprod 88(5): 123. PMID: [23553430] Shen, C., Kuang, Y., Liu, J., Feng, J., Chen, X., Wu, W., Chi, J., Tang, L., Wang, Y., Fei, J. and Wang, Z. (2013) Prss37 is required for male fertility in the mouse. Biol Reprod 88(5): 123. PMID: [23553430]
Functional description	The serine protease 37 precursor (Prss37), also known as Tryx2 and 1700016G05Rik, is a putative trypsin-like serine protease. Serine proteases, which have a nucleophilic Ser residue at the active site, account for approximately one-third of all known proteinases. Prss37 is highly and exclusively expressed in the testis of adult mice, especially in the elongating spermatids during spermiogenesis, and almost vanishes in the mature sperm of mice. Prss37 deficiency causes the absence of mature Adam3 in sperm and a defect in sperm migration from uterus into oviduct, which mainly accounts for male infertility of Prss37-null mice, while the defect in sperm-zona binding seems irrelevant to the fertilizing ability of Prss37(-/-) sperm.
Protein complex
Pathway
Human diseases
OMIM
Spermatogenesis failure	N/A

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatid
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Secreted

Mutation in human orthology

Variants founded in public databases

1000G (Phase 3): 191 ESP6500 (SI-V2): 58 ExAC (r0.3.1): 320 dbSNP(Build 147): 557

Variants founded in in-house datasets

Chinese health control (254): 9 European health control (283): 3 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
PRSS37	0.000010575	0.0000105114

Other information

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0006508	proteolysis	IEA
Biological Process	GO:0007339	binding of sperm to zona pellucida	IMP
Biological Process	GO:0016477	cell migration	IMP
Biological Process	GO:0051604	protein maturation	IMP
Cellular Component	GO:0005576	extracellular region	IEA
Cellular Component	GO:0005634	nucleus	ISO
Molecular Function	GO:0004252	serine-type endopeptidase activity	IEA
Molecular Function	GO:0046872	metal ion binding	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000031967	Prss37	ENSMUSP00000032106	1700003E16Rik	experimental
ENSMUSP00000031967	Prss37	ENSMUSP00000032133	Gp9	experimental
ENSMUSP00000031967	Prss37	ENSMUSP00000032203	A2m	experimental

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Protein family and Domain

Q9DAA4