FertilityOnline | Spermatogenes

Detail Information of SG000351

General information

SG ID

SG000351

Gene Name

Hsp90ab1

Gene Synonyms/Alias

90kDa, AL022974, C81438, Hsp84, Hsp84-1, Hsp90, Hspcb

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

ENSMUSG00000023944

Ensembl Protein ID

ENSMUSP00000024739 ENSMUSP00000126239 ENSMUSP00000127338 ENSMUSP00000131601
ENSMUSP00000119678

Description

Heat shock protein 90 alpha (cytosolic), class B member 1 [Mus musculus(house mouse)]

Orthology

Species	Uniprot	Gene stable ID	Gene Name
Rattus norvegicus	P34058	RGD:1303075	Hsp90ab1
Gallus gallus	Q04619	Gene:HSP90AB1	HSP90AB1
Danio rerio	O57521	ZFIN:ZDB-GENE-990415-95	hsp90ab1

More Orthology >>

Status

Reviewed functional gene

Functional information

Function in Stage

premeiotic meiotic

Function in Cell Type

Spermatocyte Spermatogonia

The information of related literature

1. Abstract
It is controversial whether a functional androgen receptor (AR) on germ cells, including spermatogonia, is essential for their development into sperm and, thus, initiation and maintenance of spermatogenesis. It was ... PMID: [23213375]

Figures for illustrating the function of this protein/gene

Kajiwara, C., Kondo, S., Uda, S., Dai, L., Ichiyanagi, T., Chiba, T., Ishido, S., Koji, T. and Udono, H. (2012) Spermatogenesis arrest caused by conditional deletion of Hsp90alpha in adult mice. Biol Open 1(10): 977-82. PMID: [23213375]

Functional description

AR,specifically chaperoned by Hsp90-alpha in spermatogonia, is critical for maintenance of established spermatogenesis and for survival of spermatocytes in adult testis,in addition to setting the first wave of spermatogenesis before puberty

Protein complex

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Complex name	Subunits(UniProt IDs)	Functional comment
9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex	P30561 O08915 P07901 P11499	The authors propose that the AhR exists in cytosol as a tetrameric species, while in the nucleus the AhR exists as a heterodimer.
Metallothionein-3 complex	P60710 Q04447 O08553 P11499 Q61696 P28184
Mt3-Hsp84-Ck complex	Q04447 P11499 P28184
Aip-Hsp90-Ahr complex	P30561 O08915 P11499	The authors suggest that AIP influences ligand receptivity and/or nuclear targeting of AhR.

Pathway

ReactomeID: R-MMU-8937144
Aryl hydrocarbon receptor signalling

Human diseases

OMIM

Spermatogenesis failure

N/A

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in ovary
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatogonium
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Cytoplasm

Mutation in human orthology

Variants founded in public databases

1000G (Phase 3): ESP6500 (SI-V2): ExAC (r0.3.1): dbSNP(Build 147):

Variants founded in in-house datasets

Chinese health control (254): European health control (283): Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
HSP90AB1	0.000028105	0.0000297098

Other information

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0001890	placenta development	IMP
Biological Process	GO:0006457	protein folding	IEA
Biological Process	GO:0006950	response to stress	IEA
Biological Process	GO:0007004	telomere maintenance via telomerase	IEA
Biological Process	GO:0009651	response to salt stress	IEA
Biological Process	GO:0010033	response to organic substance	IDA
Biological Process	GO:0019062	virion attachment to host cell	IEA
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IEA
Biological Process	GO:0031396	regulation of protein ubiquitination	IEA
Biological Process	GO:0032092	positive regulation of protein binding	IEA
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	IEA
Biological Process	GO:0033160	positive regulation of protein import into nucleus, translocation	IEA
Biological Process	GO:0035690	cellular response to drug	IEA
Biological Process	GO:0042220	response to cocaine	IEA
Biological Process	GO:0042493	response to drug	IEA
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IEA
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISS
Biological Process	GO:0045597	positive regulation of cell differentiation	IEA
Biological Process	GO:0045793	positive regulation of cell size	IEA
Biological Process	GO:0045859	regulation of protein kinase activity	IEA
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	IEA
Biological Process	GO:0051973	positive regulation of telomerase activity	IEA
Biological Process	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	IEA
Biological Process	GO:0060338	regulation of type I interferon-mediated signaling pathway	IEA
Biological Process	GO:0071157	negative regulation of cell cycle arrest	IEA
Biological Process	GO:0071353	cellular response to interleukin-4	IDA
Biological Process	GO:0071407	cellular response to organic cyclic compound	IEA
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IEA
Biological Process	GO:0097435	supramolecular fiber organization	IEA
Biological Process	GO:1901389	negative regulation of transforming growth factor beta activation	IEA
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	IEA
Biological Process	GO:1905323	telomerase holoenzyme complex assembly	IEA
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	IEA
Cellular Component	GO:0005576	extracellular region	IEA
Cellular Component	GO:0005622	intracellular	IDA
Cellular Component	GO:0005634	nucleus	IEA
Cellular Component	GO:0005737	cytoplasm	IEA
Cellular Component	GO:0005739	mitochondrion	IEA
Cellular Component	GO:0005765	lysosomal membrane	IEA
Cellular Component	GO:0005829	cytosol	IEA
Cellular Component	GO:0005886	plasma membrane	IEA
Cellular Component	GO:0008180	COP9 signalosome	IEA
Cellular Component	GO:0009986	cell surface	IEA
Cellular Component	GO:0016020	membrane	IEA
Cellular Component	GO:0016234	inclusion body	IEA
Cellular Component	GO:0016323	basolateral plasma membrane	IEA
Cellular Component	GO:0016324	apical plasma membrane	IEA
Cellular Component	GO:0031526	brush border membrane	IEA
Cellular Component	GO:0034751	aryl hydrocarbon receptor complex	IEA
Cellular Component	GO:0042470	melanosome	IEA
Cellular Component	GO:0043234	protein complex	IEA
Cellular Component	GO:0070062	extracellular exosome	IEA
Cellular Component	GO:1990913	sperm head plasma membrane	IEA
Cellular Component	GO:1990917	ooplasm	IEA
Molecular Function	GO:0000166	nucleotide binding	IEA
Molecular Function	GO:0001948	glycoprotein binding	IEA
Molecular Function	GO:0002134	UTP binding	IEA
Molecular Function	GO:0002135	CTP binding	IEA
Molecular Function	GO:0003723	RNA binding	IEA
Molecular Function	GO:0003725	double-stranded RNA binding	ISO
Molecular Function	GO:0005515	protein binding	IPI
Molecular Function	GO:0005524	ATP binding	IEA
Molecular Function	GO:0005525	GTP binding	IEA
Molecular Function	GO:0008144	drug binding	IEA
Molecular Function	GO:0017098	sulfonylurea receptor binding	IEA
Molecular Function	GO:0019887	protein kinase regulator activity	IMP
Molecular Function	GO:0019900	kinase binding	IPI
Molecular Function	GO:0019901	protein kinase binding	IEA
Molecular Function	GO:0023026	MHC class II protein complex binding	IEA
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	ISS
Molecular Function	GO:0030911	TPR domain binding	ISS
Molecular Function	GO:0031072	heat shock protein binding	IEA
Molecular Function	GO:0032564	dATP binding	IEA
Molecular Function	GO:0042277	peptide binding	IEA
Molecular Function	GO:0042803	protein homodimerization activity	IEA
Molecular Function	GO:0042826	histone deacetylase binding	IEA
Molecular Function	GO:0043008	ATP-dependent protein binding	IEA
Molecular Function	GO:0044325	ion channel binding	IEA
Molecular Function	GO:0045296	cadherin binding	IEA
Molecular Function	GO:0046983	protein dimerization activity	IEA
Molecular Function	GO:0051082	unfolded protein binding	IEA
Molecular Function	GO:0070182	DNA polymerase binding	IEA
Molecular Function	GO:0097718	disordered domain specific binding	IEA
Molecular Function	GO:1990226	histone methyltransferase binding	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000024739	Hsp90ab1	ENSMUSP00000024742	Nfkbie	experimental
ENSMUSP00000024739	Hsp90ab1	ENSMUSP00000024749	Polh	experimental
ENSMUSP00000024739	Hsp90ab1	ENSMUSP00000024782	Pgc	experimental

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Protein family and Domain

P11499