FertilityOnline | Spermatogenes

Detail Information of SG001185

SG ID

SG001185

Gene Name

Mea1

Gene Synonyms/Alias

Mea-1

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

Ensembl Protein ID

Description

Male enhanced antigen 1 [Mus musculus (house mouse)]

Orthology

Status

Reviewed functional gene

Function in Stage	meiotic postmeiotic
Function in Cell Type	Spermatid Spermatocyte
The information of related literature	1. Abstract The male-enhanced antigen-1 gene (Mea1) was originally isolated from a murine testicular cDNA library using anti-H-Y antigen antisera and was assigned to chromosome 17. On analysis of its structure and expression, we ... PMID: [12444059]
Figures for illustrating the function of this protein/gene	Y. Ohinata, S. Sutou, M. Kondo, T. Takahashi and Y. Mitsui (2002) Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Biol Reprod 67(6): 1824-31. PMID: [12444059] Y. Ohinata, S. Sutou, M. Kondo, T. Takahashi and Y. Mitsui (2002) Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Biol Reprod 67(6): 1824-31. PMID: [12444059] Y. Ohinata, S. Sutou, M. Kondo, T. Takahashi and Y. Mitsui (2002) Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Biol Reprod 67(6): 1824-31. PMID: [12444059]
Functional description	Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis, and is highly expressed in testis.
Protein complex
Pathway
Human diseases
OMIM
Spermatogenesis failure	N/A

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatid
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	-

Variants founded in public databases

1000G (Phase 3): 44 ESP6500 (SI-V2): 38 ExAC (r0.3.1): 203 dbSNP(Build 147): 273

Variants founded in in-house datasets

Chinese health control (254): 1 European health control (283): 1 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
MEA1	0.0000069815	0.00000789038

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0007275	multicellular organism development	IEA
Biological Process	GO:0007283	spermatogenesis	IEA
Biological Process	GO:0030154	cell differentiation	IEA
Cellular Component	GO:0005737	cytoplasm	IDA

Protein-Protein interaction information

Protein family and Domain